In vivo BLyS/BAFF neutralization ameliorates islet-directed autoimmunity in nonobese diabetic mice
G Zekavat, SY Rostami, A Badkerhanian… - The Journal of …, 2008 - journals.aai.org
B lymphocytes are required for the pathogenesis of autoimmune diabetes in NOD mice.
Previous studies established that a lymphopenic transitional (TR) B cell compartment …
Previous studies established that a lymphopenic transitional (TR) B cell compartment …
BAFF regulates activation of self‐reactive T cells through B‐cell dependent mechanisms and mediates protection in NOD mice
E Marino, SN Walters, JE Villanueva… - European journal of …, 2014 - Wiley Online Library
Targeting the BAFF/APRIL system has shown to be effective in preventing T‐cell dependent
autoimmune disease in the NOD mouse, a spontaneous model of type 1 diabetes. In this …
autoimmune disease in the NOD mouse, a spontaneous model of type 1 diabetes. In this …
Transient BAFF blockade inhibits type 1 diabetes development in nonobese diabetic mice by enriching immunoregulatory B lymphocytes sensitive to deletion by anti …
Q Wang, JJ Racine, JJ Ratiu, S Wang… - The Journal of …, 2017 - journals.aai.org
In NOD mice and also likely humans, B lymphocytes play an important role as APC-
expanding autoreactive T cell responses ultimately causing type 1 diabetes (T1D). Currently …
expanding autoreactive T cell responses ultimately causing type 1 diabetes (T1D). Currently …
B-1a lymphocytes attenuate insulin resistance
Obesity-associated insulin resistance, a common precursor of type 2 diabetes, is
characterized by chronic inflammation of tissues, including visceral adipose tissue (VAT) …
characterized by chronic inflammation of tissues, including visceral adipose tissue (VAT) …
CD4+CD25+ T-Cells Control Autoimmunity in the Absence of B-Cells
E Marino, J Villanueva, S Walters, D Liuwantara… - Diabetes, 2009 - Am Diabetes Assoc
OBJECTIVE Tumor necrosis factor ligand family members B-cell–activating factor (BAFF)
and a proliferation-inducing ligand (APRIL) can exert powerful effects on B-cell activation …
and a proliferation-inducing ligand (APRIL) can exert powerful effects on B-cell activation …
Murine islet allograft tolerance upon blockade of the B-lymphocyte stimulator, BLyS/BAFF
RF Parsons, M Yu, K Vivek, G Zekavat… - …, 2012 - journals.lww.com
Background. Immunologic rejection is a major barrier to successful long-term outcomes in
clinical transplantation. The importance of B lymphocytes—and their secretory products …
clinical transplantation. The importance of B lymphocytes—and their secretory products …
BAFF-driven autoimmunity requires CD19 expression
B cell activating factor of the tumor necrosis factor family (BAFF or BLyS) is a critical factor for
B cell survival and maturation. BAFF-transgenic (BAFF-Tg) mice develop autoimmunity that …
B cell survival and maturation. BAFF-transgenic (BAFF-Tg) mice develop autoimmunity that …
Deleting the BAFF receptor TACI protects against systemic lupus erythematosus without extensive reduction of B cell numbers
B cell-activating factor of the TNF family (BAFF) is an essential B cell survival factor.
However, high levels of BAFF promote systemic lupus erythematosus (SLE) in mice and …
However, high levels of BAFF promote systemic lupus erythematosus (SLE) in mice and …
Cutting edge: a role for B lymphocyte stimulator in systemic lupus erythematosus
J Zhang, V Roschke, KP Baker, Z Wang… - The Journal of …, 2001 - journals.aai.org
Increased levels of B lymphocyte stimulator (BLyS) are associated with systemic
autoimmunity in animal models of spontaneous autoimmune disease, and transgenic …
autoimmunity in animal models of spontaneous autoimmune disease, and transgenic …
Cutting edge: BAFF promotes autoantibody production via TACI-dependent activation of transitional B cells
HM Jacobs, CD Thouvenel, S Leach… - The Journal of …, 2016 - journals.aai.org
Mice overexpressing B cell activating factor of the TNF family (BAFF) develop systemic
autoimmunity characterized by class-switched anti-nuclear Abs. Transmembrane activator …
autoimmunity characterized by class-switched anti-nuclear Abs. Transmembrane activator …