TACI‐dependent APRIL signaling maintains autoreactive B cells in a mouse model of systemic lupus erythematosus
NL Tran, P Schneider… - European journal of …, 2017 - Wiley Online Library
Autoantibodies contribute to the development of systemic lupus erythematosus (SLE). APRIL
(a proliferation‐inducing ligand), a member of the TNF superfamily, regulates plasma‐cell …
(a proliferation‐inducing ligand), a member of the TNF superfamily, regulates plasma‐cell …
BLyS-mediated modulation of naive B cell subsets impacts HIV Env-induced antibody responses
P Dosenovic, M Soldemo, JL Scholz… - The Journal of …, 2012 - journals.aai.org
Neutralizing Abs provide the protective effect of the majority of existing human vaccines. For
a prophylactic vaccine against HIV-1, broadly neutralizing Abs targeting conserved epitopes …
a prophylactic vaccine against HIV-1, broadly neutralizing Abs targeting conserved epitopes …
Targeting B lymphocyte stimulator in systemic lupus erythematosus and other autoimmune rheumatic disorders
W Stohl - Expert Opinion on Therapeutic Targets, 2004 - Taylor & Francis
B lymphocyte stimulator (BLyS) is a vital B cell survival factor. Overexpression of BLyS in
mice can lead to systemic lupus erythematosus (SLE)-like disease and to Sjögren's …
mice can lead to systemic lupus erythematosus (SLE)-like disease and to Sjögren's …
The role of B lymphocyte stimulator in B cell biology: implications for the treatment of lupus
B lymphocyte stimulator (BLyS; also known as B cell activating factor (BAFF)) plays a key
role in peripheral B cell tolerance. Mounting evidence indicates that B cell tolerance can be …
role in peripheral B cell tolerance. Mounting evidence indicates that B cell tolerance can be …
BLyS—an essential survival factor for B cells: basic biology, links to pathology and therapeutic target
KP Baker - Autoimmunity reviews, 2004 - Elsevier
A paradigm shift in our understanding of autoimmune disease pathology is underway; B
cells are now considered to play a central role in disease pathogenesis. Targeting B cells …
cells are now considered to play a central role in disease pathogenesis. Targeting B cells …
To B or not to B: TNF family signaling in lymphocytes
RM Siegel, MJ Lenardo - Nature Immunology, 2001 - nature.com
BLyS and family are known to affect B cells in a positive fashion. Knock-outs of BLyS
receptors indicate some new functions, including negative regulation by one BLyS receptor …
receptors indicate some new functions, including negative regulation by one BLyS receptor …
Cutting edge: BAFF overexpression reduces atherosclerosis via TACI-dependent B cell activation
Patients with systemic lupus erythematosus exhibit accelerated atherosclerosis, a chronic
inflammatory disease of the arterial wall. The impact of B cells in atherosclerosis is …
inflammatory disease of the arterial wall. The impact of B cells in atherosclerosis is …
BAFF regulates follicular helper T cells and affects their accumulation and interferon‐γ production in autoimmunity
CM Coquery, WM Loo, NS Wade… - Arthritis & …, 2015 - Wiley Online Library
Objective Follicular helper T (Tfh) cells are critical for the development of protective
antibodies via germinal center (GC) B cell responses; however, uncontrolled Tfh cell …
antibodies via germinal center (GC) B cell responses; however, uncontrolled Tfh cell …
[HTML][HTML] Attenuation of apoptosis underlies B lymphocyte stimulator enhancement of humoral immune response
RKG Do, E Hatada, H Lee, MR Tourigny… - The Journal of …, 2000 - ncbi.nlm.nih.gov
B lymphocyte stimulator (BLyS) is a newly identified monocyte-specific TNF family cytokine.
It has been implicated in the development of autoimmunity, and functions as a potent …
It has been implicated in the development of autoimmunity, and functions as a potent …
BAFF-targeting therapy, a promising strategy for treating autoimmune diseases
J Sun, Z Lin, J Feng, Y Li, B Shen - European journal of pharmacology, 2008 - Elsevier
Since B cell activating factor belonging to tumor necrosis factor (TNF) family (BAFF) has
been identified as a critical factor for B cell maturation and survival, convincing evidence …
been identified as a critical factor for B cell maturation and survival, convincing evidence …