Autoantibodies contribute to the development of systemic lupus erythematosus (SLE). APRIL
(a proliferation‐inducing ligand), a member of the TNF superfamily, regulates plasma‐cell …

Neutralizing Abs provide the protective effect of the majority of existing human vaccines. For
a prophylactic vaccine against HIV-1, broadly neutralizing Abs targeting conserved epitopes …

B lymphocyte stimulator (BLyS) is a vital B cell survival factor. Overexpression of BLyS in
mice can lead to systemic lupus erythematosus (SLE)-like disease and to Sjögren's …

B lymphocyte stimulator (BLyS; also known as B cell activating factor (BAFF)) plays a key
role in peripheral B cell tolerance. Mounting evidence indicates that B cell tolerance can be …

A paradigm shift in our understanding of autoimmune disease pathology is underway; B
cells are now considered to play a central role in disease pathogenesis. Targeting B cells …

BLyS and family are known to affect B cells in a positive fashion. Knock-outs of BLyS
receptors indicate some new functions, including negative regulation by one BLyS receptor …

Patients with systemic lupus erythematosus exhibit accelerated atherosclerosis, a chronic
inflammatory disease of the arterial wall. The impact of B cells in atherosclerosis is …

Objective Follicular helper T (Tfh) cells are critical for the development of protective
antibodies via germinal center (GC) B cell responses; however, uncontrolled Tfh cell …

B lymphocyte stimulator (BLyS) is a newly identified monocyte-specific TNF family cytokine.
It has been implicated in the development of autoimmunity, and functions as a potent …

Since B cell activating factor belonging to tumor necrosis factor (TNF) family (BAFF) has
been identified as a critical factor for B cell maturation and survival, convincing evidence …