Regulation of the B cell receptor repertoire and self-reactivity by BAFF
M Ota, BH Duong, A Torkamani, CM Doyle… - The Journal of …, 2010 - journals.aai.org
The TNF-family cytokine BAFF (BLyS) promotes B lymphocyte survival and is overexpressed
in individuals with systemic lupus erythematosus and Sjögren's Syndrome. BAFF can rescue …
in individuals with systemic lupus erythematosus and Sjögren's Syndrome. BAFF can rescue …
Mechanism of BLyS action in B cell immunity
RKG Do, S Chen-Kiang - Cytokine & growth factor reviews, 2002 - Elsevier
The B lymphocyte stimulator (BLyS), also known as BAFF, THANK, TALL-1 and zTNF4, is
the most recent addition to the tumor necrosis factor family (TNF) ligands and has a unique …
the most recent addition to the tumor necrosis factor family (TNF) ligands and has a unique …
BLyS and April serum levels in patients with autoimmune thyroid diseases
M Fabris, F Grimaldi, D Villalta, A Picierno, C Fabro… - Autoimmunity …, 2010 - Elsevier
Elevated B-Lymphocyte Stimulator (BLyS) and April (a proliferation-inducing ligand)
expressions characterize several autoimmune diseases. We here analysed the possible role …
expressions characterize several autoimmune diseases. We here analysed the possible role …
Constitutive overexpression of BAFF in autoimmune‐resistant mice drives only some aspects of systemic lupus erythematosus–like autoimmunity
W Stohl, N Jacob, S Guo, L Morel - Arthritis & Rheumatism, 2010 - Wiley Online Library
Objective To determine whether overexpression of BAFF can promote systemic lupus
erythematosus (SLE)–like autoimmunity in mice that are otherwise autoimmune‐resistant …
erythematosus (SLE)–like autoimmunity in mice that are otherwise autoimmune‐resistant …
A therapeutic role for BLyS antagonists
W Stohl - Lupus, 2004 - journals.sagepub.com
B lymphocytestimulator (BLyS) is a vital B cell survivalfactor. Overexpressionof BLyS in mice
may lead to systemic lupus erythematosus (SLE)-like disease, and treatment of bona fide …
may lead to systemic lupus erythematosus (SLE)-like disease, and treatment of bona fide …
B cells and the BAFF/APRIL axis: fast-forward on autoimmunity and signaling
B-cell activation factor from the tumor necrosis factor family (BAFF) is a key survival factor
during B-cell maturation—a delicate immune checkpoint for B cells. Excessive BAFF …
during B-cell maturation—a delicate immune checkpoint for B cells. Excessive BAFF …
A role for BLyS in the activation of innate immune cells
SK Chang, BK Arendt, JR Darce, X Wu, DF Jelinek - Blood, 2006 - ashpublications.org
B-lymphocyte stimulator (BLyS) is a member of the tumor necrosis factor (TNF) ligand
superfamily. Although BLyS costimulates adaptive immune cells, the ability of BLyS to …
superfamily. Although BLyS costimulates adaptive immune cells, the ability of BLyS to …
BlySfulness does not equal blissfulness in systemic lupus erythematosus: a therapeutic role for BLyS antagonists
W Stohl - B Cell Trophic Factors and B Cell Antagonism in …, 2005 - karger.com
B lymphocyte stimulator (BLyS) is a vital B cell survival factor. Constitutive overexpression of
BLyS in mice can lead to systemic lupus erythematosus (SLE)-like disease. Mice which …
BLyS in mice can lead to systemic lupus erythematosus (SLE)-like disease. Mice which …
BLyS inhibition eliminates primary B cells but leaves natural and acquired humoral immunity intact
JL Scholz, JE Crowley, MM Tomayko… - Proceedings of the …, 2008 - National Acad Sciences
We have used an inhibiting antibody to determine whether preimmune versus antigen-
experienced B cells differ in their requisites for BLyS, a cytokine that controls differentiation …
experienced B cells differ in their requisites for BLyS, a cytokine that controls differentiation …
Alteration of B cell subsets and the receptor for B cell activating factor (BAFF) in paediatric patients with type 1 diabetes
Z Parackova, A Klocperk, M Rataj, J Kayserova… - Immunology letters, 2017 - Elsevier
Background Lately, mounting evidence has shown that B cells play an important role in the
pathogenesis of type 1 diabetes (T1D). Here, we present alterations in B cell subsets …
pathogenesis of type 1 diabetes (T1D). Here, we present alterations in B cell subsets …