BLyS and APRIL are tumor necrosis factor superfamily members shown to be important for B-
cell development, maturation and survival. Recent data also indicate that these cytokines …

BLyS, a key cytokine that sustains B cell maturation and tolerance, binds three receptors:
BR3, BCMA, and TACI. Results from knockout mice implicate a major functional role for BR3 …

BAFF (BLyS) and APRIL are TNF-like cytokines that support survival and differentiation of B
cells. Recent studies have discovered a role for BAFF in augmenting both innate and …

Objective Dysregulated APRIL/BAFF signaling is implicated in the pathogenesis of multiple
autoimmune diseases, including systemic lupus erythematosus and lupus nephritis. We …

B cells play a pivotal role in autoimmunity not only by producing pathogenic autoantibodies
but also by modulating immune responses via the production of cytokines and chemokines …

The story of B lymphocyte stimulator (BLyS [trademark of Human Genome Sciences,
Rockville, MD], BAFF, and others) is one of the most remarkable in recent biology. Less than …

Introduction: B lymphocyte stimulator (BLyS) is a major regulatory factor that controls the
development and survival of B cells. Elevated serum levels of BLyS have been associated …

Objectives. To investigate the role of B-Lymphocyte stimulator (BLyS) in mixed
cryoglobulinaemia syndrome (MCsn), a systemic vasculitis associated with a high risk to …

We have assessed the role of B lymphocyte stimulator (BLyS) and its receptors in the
germinal center (GC) reaction and affinity maturation. Despite ample BLyS retention on B …

Autoreactive B cells are one of the key immune cells that have been implicated in the
pathogenesis of systemic lupus erythematosus (SLE). In addition to the production of …