Efficacy and Mechanisms of Mild Therapeutic Hypothermia for Hearing Preservation from Noise-Induced Hearing Loss

SR Sabatino - scholarship.miami.edu
Noise-induced hearing loss (NIHL) is an acquired form of sensorineural hearing loss
associated with cochlear trauma in response to acoustic over-stimulation. NIHL may present …

[PDF][PDF] Efficacy and Mechanisms of Mild Therapeutic Hypothermia for Hearing Preservation from Noise-Induced Hearing Loss

S Rincon Sabatino - 2023 - scholarship.miami.edu
Noise-induced hearing loss (NIHL) is an acquired form of sensorineural hearing loss
associated with cochlear trauma in response to acoustic over-stimulation. NIHL may present …

Targeted therapeutic hypothermia protects against noise induced hearing loss

S Rincon Sabatino, A Rivero, R Sangaletti… - Frontiers in …, 2024 - frontiersin.org
Introduction Exposure to occupational or recreational loud noise activates multiple biological
regulatory circuits and damages the cochlea, causing permanent changes in hearing …

Transcriptional response to mild therapeutic hypothermia in noise-induced cochlear injury

S Rincon Sabatino, R Sangaletti, A Griswold… - Frontiers in …, 2024 - frontiersin.org
Introduction Prevention or treatment for acoustic injury has been met with many translational
challenges, resulting in the absence of FDA-approved interventions. Localized hypothermia …

Achieving Cochlear Therapeutic Hypothermia through Irrigation of the Mastoid and Tympanic Cavities

B Beatrous, AA Arteaga, E Mckee… - Audiology and …, 2024 - karger.com
Introduction: Mild therapeutic hypothermia (MTH) is an exciting nonpharmaceutical
otoprotection strategy. In this study, we applied simple irrigation of the tympanic and mastoid …

Theoretical evaluation and experimental validation of localized therapeutic hypothermia application to preserve residual hearing after cochlear implantation

I Tamames, C King, CY Huang, FF Telischi… - Ear and …, 2018 - journals.lww.com
Objectives: Cochlear implantation surgery has been shown to result in trauma to inner ear
sensory structures, resulting in loss of residual hearing. Localized therapeutic hypothermia …

Achieving mild therapeutic hypothermia in the human cochlea

AA Arteaga, B Beatrous, TL Eby, J Smith… - Otology & …, 2023 - journals.lww.com
Achieving Mild Therapeutic Hypothermia in the Human Cochlea : Otology & Neurotology
Achieving Mild Therapeutic Hypothermia in the Human Cochlea : Otology & Neurotology Log …

Mild therapeutic hypothermia protects against inflammatory and proapoptotic processes in the rat model of cochlear implant trauma

R Sangaletti, I Tamames, SL Yahn, JS Choi, JK Lee… - Hearing research, 2023 - Elsevier
Objective Mild therapeutic hypothermia (MTH) has been demonstrated to prevent residual
hearing loss from surgical trauma associated with cochlear implant (CI) insertion. Here, we …

Induction of localized cochlear hypothermia

LP Smith, AA Eshraghi, DE Whitley… - Acta oto …, 2007 - Taylor & Francis
Conclusions. Localized cochlear hypothermia was induced in a rat model, demonstrating
the feasibility of modulating cochlear temperature without affecting core body temperature …

Local to systemic use of hypothermia

M Kurz, P Lyden, J Lundbye… - Therapeutic hypothermia …, 2018 - liebertpub.com
During the 2017 Chilling at the Beach Annual Meeting in Miami, an Expert Panel Discussion
was conducted on the use of local or systemic therapeutic hypothermia in several clinical …