Object. Previous studies undertaken by the authors have indicated that iron accumulation
and oxidative stress in the brain contribute to secondary brain damage after intracerebral …

Iron overload occurs in brain after intracerebral hemorrhage (ICH). Deferoxamine, an iron
chelator, attenuates perihematomal edema and oxidative stress in brain after ICH. We …

We investigated the occurrence of DNA damage in brain after intracerebral hemorrhage
(ICH) and the role of iron in such injury. Male Sprague-Dawley rats received an infusion of …

The purpose of this study was to investigate hemoglobin and iron handling after
subarachnoid hemorrhage (SAH), examine the relationship between iron and neuroglial cell …

Iron-mediated free radical damage contributes to secondary damage after intracerebral
hemorrhage (ICH). Iron is released from heme after hemoglobin breakdown and …

Object Intracerebral hemorrhage (ICH) causes brain atrophy and neurological deficits. The
mechanisms of brain atrophy after ICH are poorly understood, although recent evidence …

Background and Purpose—Our previous studies found that deferoxamine reduces
intracerebral hemorrhage (ICH)-induced brain injury in rats. The current study examined …

Background Hemoglobin degradation products, in particular iron, have been implicated in
secondary neuronal injury following intracerebral hemorrhage (ICH). The iron chelator …

Intracerebral hemorrhage (ICH) is a devastating form of stroke. In this study, we examined
the efficacy of deferoxamine (DFX), an iron chelator, after collagenase-induced ICH in 12 …

Iron resulting from hemoglobin degradation is linked to delayed neuronal injury after
intracerebral hemorrhage. Extensive preclinical investigations indicate that the iron chelator …