The loss of muscle strength with age has been studied from the perspective of a decline in
muscle mass and neuromuscular junction (NMJ) stability. A third potential factor is force …

Key points Force transfer is integral for maintaining skeletal muscle structure and function.
One important component is dystrophin. There is limited understanding of how force transfer …

This study tested the hypothesis that age-related changes in the dystrophin–glycoprotein
complex (DGC) may precede age-associated alterations in muscle morphology and …

Duchenne muscular dystrophy (DMD) is caused by the absence of a functional dystrophin
protein and is modeled by the mdx mouse. The mdx mouse suffers an early necrotic bout in …

Physical inactivity (PI) is a major risk factor of chronic diseases. A major aspect of PI is loss
of muscle mass and strength. The latter phenomenon significantly impacts daily life and …

Age-related loss of muscle mass and strength can be accelerated by impaired recovery of
muscle mass following a transient atrophic stimulus. The aim of this study was to identify the …

Background Aging skeletal muscle frequently exhibits a reduction in force produced per unit
muscle tissue, variously termed muscle quality, specific tension or dynapenia. Muscles from …

X‐linked muscular dystrophy is a highly progressive disease of childhood and characterized
by primary genetic abnormalities in the dystrophin gene. Senescent mdx specimens were …

Background The greater susceptibility to contraction-induced skeletal muscle injury (fragility)
is an important dystrophic feature and tool for testing preclinic dystrophin-based therapies …

The MDX mouse is an animal model of Duchenne muscular dystrophy, a human disease
marked by an absence of the cytoskeletal protein, dystrophin. We hypothesized that 1) …