Disturbances in vascular function contribute to the development of several diseases of
increasing prevalence and thereby contribute significantly to human mortality and morbidity …

Lining the inner surface of the circulatory system, the vascular endothelium accomplishes a
vast variety of specialized functions. Even slight alterations of these functions are implicated …

The endothelium is vital to the proper functioning in the heart, in particular due to its
production of nitric oxide (NO) which regulates vascular tone. Damage to the endothelium …

The mitochondria are essential organelles that generate large amounts of ATP via the
electron transport chain (ECT). Mitochondrial dysfunction causes reactive oxygen species …

In contrast to their role in cell types with higher energy demands, mitochondria in endothelial
cells primarily function in signaling cellular responses to environmental cues. This article …

Mitochondria are perhaps the most sophisticated and dynamic responsive sensing systems
in eukaryotic cells. The role of mitochondria goes beyond their capacity to create molecular …

Mitochondria have long been known to play a critical role in maintaining the bioenergetic
status of cells under physiological conditions. It was also recognized early in mitochondrial …

Once thought of as toxic by-products of cellular metabolism, reactive oxygen species (ROS)
have been implicated in a large variety of cell-signaling processes. Several enzymatic …

Mitochondria are well known for their central roles in ATP production, calcium homeostasis,
and heme and steroid biosynthesis. However, mitochondrial reactive oxygen species (ROS) …

Mitochondria are often regarded as the powerhouse of the cell by generating the ultimate
energy transfer molecule, ATP, which is required for a multitude of cellular processes …