Environmental risk factors and multiple sclerosis: an umbrella review of systematic reviews and meta-analyses

L Belbasis, V Bellou, E Evangelou… - The Lancet …, 2015 - thelancet.com
Background The cause of multiple sclerosis is believed to involve environmental exposure
and genetic susceptibility. We aimed to summarise the environmental risk factors that have …

Environmental factors and risk of multiple sclerosis: findings from meta-analyses and Mendelian randomization studies

L Belbasis, V Bellou, E Evangelou… - Multiple Sclerosis …, 2020 - journals.sagepub.com
Multiple sclerosis (MS) is a chronic demyelinating disease that is associated with permanent
disability and low quality of life. Development of MS is attributed to a combination of genetic …

Role of environmental factors in multiple sclerosis

A Zarghami, Y Li, SB Claflin, I van der Mei… - Expert Review of …, 2021 - Taylor & Francis
Introduction Environmental factors play a significant role in the pathogenesis and
progression of multiple sclerosis (MS), either acting alone or by interacting with other …

Environmental modifiable risk factors for multiple sclerosis: Report from the 2016 ECTRIMS focused workshop

MP Amato, T Derfuss, B Hemmer… - Multiple Sclerosis …, 2018 - journals.sagepub.com
Multiple sclerosis (MS) is an inflammatory and neurodegenerative demyelinating disease of
the central nervous system (CNS), most likely autoimmune in origin, usually beginning in …

Environmental factors and their timing in adult-onset multiple sclerosis

AE Handel, G Giovannoni, GC Ebers… - Nature Reviews …, 2010 - nature.com
Multiple sclerosis (MS) is a common, complex neurological disease. Epidemiological data
implicate both genetic and environmental factors in the etiology of MS, with various factors …

Environmental risk factors in multiple sclerosis aetiology

RA Marrie - The Lancet Neurology, 2004 - thelancet.com
The epidemiology of multiple sclerosis (MS) has been intensively studied. It is
conceptualised as a complex disease in which genetic and environmental factors act …

Environmental risk factors for multiple sclerosis. Part II: Noninfectious factors

A Ascherio, KL Munger - … of Neurology: Official Journal of the …, 2007 - Wiley Online Library
As discussed in Part I of this review, the geographic distribution of multiple sclerosis (MS)
and the change in risk among migrants provide compelling evidence for the existence of …

Environmental risk factors in multiple sclerosis

M Pugliatti, HF Harbo, T Holmøy… - Acta Neurologica …, 2008 - Wiley Online Library
Objectives–Multiple sclerosis (MS) likely results from an interaction between genetic and
exogenous factors. While genetics shapes the overall population MS susceptibility …

An atlas on risk factors for multiple sclerosis: a Mendelian randomization study

S Yuan, Y Xiong, SC Larsson - Journal of neurology, 2021 - Springer
Objectives We conducted a systematic review and wide-angled Mendelian randomization
(MR) study to examine the association between possible risk factors and multiple sclerosis …

Environmental risk factors in multiple sclerosis

K Lauer - Expert review of neurotherapeutics, 2010 - Taylor & Francis
The etiology of multiple sclerosis is, at present, not definitely known, but genetic and
environmental factors play a role in its causation. Environmental causes have a predominant …