Is mitochondrial dysfunction a common root of noncommunicable chronic diseases?
A Diaz-Vegas, P Sanchez-Aguilera, JR Krycer… - Endocrine …, 2020 - academic.oup.com
Mitochondrial damage is implicated as a major contributing factor for a number of
noncommunicable chronic diseases such as cardiovascular diseases, cancer, obesity, and …
noncommunicable chronic diseases such as cardiovascular diseases, cancer, obesity, and …
Mitochondria and metabolic homeostasis
Mitochondrial function is fundamental to metabolic homeostasis. In addition to converting the
nutrient flux into the energy molecule ATP, the mitochondria generate intermediates for …
nutrient flux into the energy molecule ATP, the mitochondria generate intermediates for …
Mitochondrial function and endocrine diseases
R Stark, M Roden - European journal of clinical investigation, 2007 - Wiley Online Library
Mitochondria are fundamental for oxidative energy production and impairment of their
functionality can lead to reduced ATP synthesis and contribute to initiation of apoptosis …
functionality can lead to reduced ATP synthesis and contribute to initiation of apoptosis …
[HTML][HTML] Mitochondrial dysfunction and oxidative stress in metabolic disorders—A step towards mitochondria based therapeutic strategies
Mitochondria are the powerhouses of the cell and are involved in essential functions of the
cell, including ATP production, intracellular Ca 2+ regulation, reactive oxygen species …
cell, including ATP production, intracellular Ca 2+ regulation, reactive oxygen species …
The key role of mitochondrial function in health and disease
I San-Millán - Antioxidants, 2023 - mdpi.com
The role of mitochondrial function in health and disease has become increasingly
recognized, particularly in the last two decades. Mitochondrial dysfunction as well as …
recognized, particularly in the last two decades. Mitochondrial dysfunction as well as …
Mitochondria: in sickness and in health
J Nunnari, A Suomalainen - Cell, 2012 - cell.com
Mitochondria perform diverse yet interconnected functions, producing ATP and many
biosynthetic intermediates while also contributing to cellular stress responses such as …
biosynthetic intermediates while also contributing to cellular stress responses such as …
Mitochondria at work: new insights into regulation and dysregulation of cellular energy supply and metabolism
V Schirrmacher - Biomedicines, 2020 - mdpi.com
Mitochondria are of great relevance to health, and their dysregulation is associated with
major chronic diseases. Research on mitochondria—156 brand new publications from 2019 …
major chronic diseases. Research on mitochondria—156 brand new publications from 2019 …
[HTML][HTML] Mitochondrial dysfunction in type 2 diabetes mellitus: an organ-based analysis
Type 2 diabetes mellitus (T2DM) is a systemic disease characterized by hyperglycemia,
hyperlipidemia, and organismic insulin resistance. This pathological shift in both circulating …
hyperlipidemia, and organismic insulin resistance. This pathological shift in both circulating …
Repairing mitochondrial dysfunction in disease
V Sorrentino, KJ Menzies… - Annual review of …, 2018 - annualreviews.org
Mitochondria are essential organelles for many aspects of cellular homeostasis, including
energy harvesting through oxidative phosphorylation. Alterations of mitochondrial function …
energy harvesting through oxidative phosphorylation. Alterations of mitochondrial function …
Mitochondria in health, disease, and aging
JS Harrington, SW Ryter, M Plataki… - Physiological …, 2023 - journals.physiology.org
Mitochondria are well known as organelles responsible for the maintenance of cellular
bioenergetics through the production of ATP. Although oxidative phosphorylation may be …
bioenergetics through the production of ATP. Although oxidative phosphorylation may be …
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