Glioblastoma multiforme: an overview of emerging therapeutic targets

OG Taylor, JS Brzozowski, KA Skelding - Frontiers in oncology, 2019 - frontiersin.org
Glioblastoma multiforme (GBM) is the most common and aggressive malignant primary brain
tumour in humans and has a very poor prognosis. The existing treatments have had limited …

Molecular targeted therapies in glioblastoma multiforme: a systematic overview of global trends and findings

E Begagić, R Pugonja, H Bečulić, A Čeliković… - Brain Sciences, 2023 - mdpi.com
This systematic review assesses current molecular targeted therapies for glioblastoma
multiforme (GBM), a challenging condition with limited treatment options. Using PRISMA …

Recent advances in the therapeutic strategies of glioblastoma multiforme

AF Aldoghachi, AF Aldoghachi, K Breyne, KH Ling… - Neuroscience, 2022 - Elsevier
Glioblastoma multiforme (GBM) is one of the most common, most formidable, and deadliest
malignant types of primary astrocytoma with a poor prognosis. At present, the standard of …

On glioblastoma and the search for a cure: where do we stand?

J Bianco, C Bastiancich, A Jankovski… - Cellular and Molecular …, 2017 - Springer
Although brain tumours have been documented and recorded since the nineteenth century,
2016 marked 90 years since Percival Bailey and Harvey Cushing coined the term …

Current status and future therapeutic perspectives of glioblastoma multiforme (GBM) therapy: A review

K Anjum, BI Shagufta, SQ Abbas, S Patel, I Khan… - Biomedicine & …, 2017 - Elsevier
Glioblastoma multiforme (GBM) is the deadliest form of heterogeneous brain cancer. It
affects an enormous number of patients every year and the survival is approximately 8 to 15 …

Current challenges and opportunities in treating glioblastoma

A Shergalis, A Bankhead, U Luesakul… - Pharmacological …, 2018 - ASPET
Glioblastoma multiforme (GBM), the most common and aggressive primary brain tumor, has
a high mortality rate despite extensive efforts to develop new treatments. GBM exhibits both …

[HTML][HTML] Glioblastoma multiforme: State of the art and future therapeutics

TA Wilson, MA Karajannis, DH Harter - Surgical neurology …, 2014 - ncbi.nlm.nih.gov
Background: Glioblastoma multiforme (GBM) is the most common and lethal primary
malignancy of the central nervous system (CNS). Despite the proven benefit of surgical …

Emerging treatment strategies for glioblastoma multiforme

SK Carlsson, SP Brothers… - EMBO molecular medicine, 2014 - embopress.org
Glioblastoma multiforme (GBM) is the deadliest form of brain tumor with a more than 90% 5‐
year mortality. GBM has a paltry median survival of 12.6 months attributed to the unique …

Glioblastoma multiforme: novel therapeutic targets

M Muir, S Gopakumar, J Traylor, S Lee… - Expert Opinion on …, 2020 - Taylor & Francis
Introduction The increasingly detailed genetic characterization of glioblastoma (GBM) has
failed to translate into meaningful breakthroughs in treatment. This is likely to be attributed to …

Glioblastoma multiforme: a review of where we have been and where we are going

C Adamson, OO Kanu, AI Mehta, C Di… - Expert opinion on …, 2009 - Taylor & Francis
Malignant gliomas such as glioblastoma multiforme (GBM) present some of the greatest
challenges in the management of cancer patients worldwide, despite notable recent …