Staphylococcal phages and pathogenicity islands drive plasmid evolution

S Humphrey, Á San Millán, M Toll-Riera… - Nature …, 2021 - nature.com
Conjugation has classically been considered the main mechanism driving plasmid transfer
in nature. Yet bacteria frequently carry so-called non-transmissible plasmids, raising …

Conjugative plasmid transfer is limited by prophages but can be overcome by high conjugation rates

C Igler, L Schwyter, D Gehrig… - … Transactions of the …, 2022 - royalsocietypublishing.org
Antibiotic resistance spread via plasmids is a serious threat to successfully fight infections
and makes understanding plasmid transfer in nature crucial to prevent the rise of antibiotic …

Phage-plasmids spread antibiotic resistance genes through infection and lysogenic conversion

E Pfeifer, RA Bonnin, EPC Rocha - MBio, 2022 - Am Soc Microbiol
Antibiotic resistance is rapidly spreading via the horizontal transfer of resistance genes in
mobile genetic elements. While plasmids are key drivers of this process, few integrative …

Natural and artificial strategies to control the conjugative transmission of plasmids

M Getino, F de la Cruz - Microbiology spectrum, 2018 - Am Soc Microbiol
Conjugative plasmids are the main carriers of transmissible antibiotic resistance (AbR)
genes. For that reason, strategies to control plasmid transmission have been proposed as …

An updated view of plasmid conjugation and mobilization in Staphylococcus

JP Ramsay, SM Kwong, RJT Murphy… - Mobile genetic …, 2016 - Taylor & Francis
The horizontal gene transfer facilitated by mobile genetic elements impacts almost all areas
of bacterial evolution, including the accretion and dissemination of antimicrobial-resistance …

Phage-plasmids promote recombination and emergence of phages and plasmids

E Pfeifer, EPC Rocha - Nature Communications, 2024 - nature.com
Phages and plasmids are regarded as distinct types of mobile genetic elements that drive
bacterial evolution by horizontal gene transfer. However, the distinction between both types …

Positive epistasis between co-infecting plasmids promotes plasmid survival in bacterial populations

A San Millan, K Heilbron, RC MacLean - The ISME journal, 2014 - academic.oup.com
Plasmids have a key role in the horizontal transfer of genes among bacteria. Although
plasmids are catalysts for bacterial evolution, it is challenging to understand how they can …

The F pilus serves as a conduit for the DNA during conjugation between physically distant bacteria

K Goldlust, A Ducret, M Halte… - Proceedings of the …, 2023 - National Acad Sciences
Horizontal transfer of F-like plasmids by bacterial conjugation is responsible for
disseminating antibiotic resistance and virulence determinants among pathogenic …

Unravelling bacteriophage ϕ11 requirements for packaging and transfer of mobile genetic elements in Staphylococcus aureus

N Quiles‐Puchalt, R Martínez‐Rubio… - Molecular …, 2014 - Wiley Online Library
Bacteriophages play a major role in spreading mobile genetic elements (MGEs)‐encoded
genes among bacterial populations. In spite of this, the molecular requirements for building …

[PDF][PDF] Pathogenicity island-directed transfer of unlinked chromosomal virulence genes

J Chen, G Ram, JR Penadés, S Brown, RP Novick - Molecular cell, 2015 - cell.com
In recent decades, the notorious pathogen Staphylococcus aureus has become
progressively more contagious, more virulent, and more resistant to antibiotics. This implies …