The P2Z receptor is responsible for adenosine triphosphate (ATP)-dependent lysis of
macrophages through the formation of membrane pores permeable to large molecules …

P2X receptors are trimeric ATP-activated ion channels permeable to Na+, K+ and Ca2+. The
seven P2X receptor subtypes are implicated in physiological processes that include …

P2X receptors are membrane ion channels activated by the binding of extracellular
adenosine triphosphate (ATP). For years their functional significance was consigned to …

Cation-selective P2X receptor channels were first described in sensory neurons1-4 where
they are important for primary afferent neurotransmission and nociception5, 6. Here we …

P2X2 and P2X3 are subunits of P2X receptors, cation channels opened by binding
extracellular ATP. cDNAs encoding P2X2 and P2X3 receptor subunits, each with one of two …

Extracellular ATP exerts pronounced biological actions in virtually every organ or tissue that
has been studied. In the central and peripheral nervous system, ATP acts as a fast excitatory …

P2X7 is a subtype of ATP-gated channels that is highly expressed in astrocytes, microglia,
and other immune cells. Activation of P2X7 purinoceptors by ATP or 3′-O-(4-benzoyl) …

EXTRACELLULAR ATP exerts its effects through P2 purino-ceptors1: these are ligand-gated
ion channels (P2x) 2, 3 or G-protein-coupled receptors (Piv, Piu) 4-ATP at P2X receptors …

ATP is known to depolarize sensory neurons, and may play a role in nociceptor activation
when released from damaged tissue1-10. Here we report the molecular cloning and …

P2X receptors are cation-selective ion channels gated by extracellular ATP, and are
implicated in diverse physiological processes, from synaptic transmission to inflammation to …