Abstract Hypoxia-inducible factor-1 (HIF-1) has been reported to promote tumour
radioresistance; therefore, it is recognised as an excellent target during radiation therapy …

Abstract Hypoxia-inducible factor-1 (HIF-1) plays important roles in regulating
radiosensitivity, making it a potentially promising target for tumour radiosensitisation. Here …

High levels of hypoxia inducible factor (HIF)-1α in tumors are reported to be associated with
tumor progression and resistance to therapy. To examine the impact of HIF-1α on …

Hypoxia and free radicals, such as reactive oxygen and nitrogen species, can alter the
function and/or activity of the transcription factor hypoxia-inducible factor 1 (HIF1). Interplay …

Recent advances in radiotherapy technology now enable us to deliver a booster dose of
radiation to small target fractions in a malignant tumor. To fully exploit this technology in …

PURPOSE: The transcription factor subunit hypoxia-inducible factor-1α (HIF-1α) is currently
discussed as a potential endogenous marker of tumor hypoxia to select patients for modified …

Background: Radiotherapy is one of the most widely used treatments for cancer. The benefit
of radiation is known to be negatively affected by tumor hypoxia and the expression of …

BACKGROUND AND PURPOSE: To test the hypothesis that deficiency in expression of the
transcription factor, HIF-1, renders tumours more radioresponsive than HIF-1 proficient …

Hypoxia is a common phenomenon in human solid tumors and has been considered as an
important, independent negative prognostic factor for response to treatment and survival of …

Abstract Hypoxia-inducible factor-1 (HIF-1) stabilization is a pivotal event in the response to
hypoxic stress. A study in the December 15, 2006 issue of Cancer Research shows that HIF …