Adaptive immunity, orchestrated by B-cells and T-cells, plays a crucial role in protecting the
body from pathogenic invaders and can be used as tools to enhance the body's defense …

Cancer is among the leading causes of death worldwide. Therefore, improving cancer
therapeutic strategies using novel alternatives is a top priority on the contemporary scientific …

Adoptive cell therapy (ACT) has seen a steep rise of new therapeutic approaches in its
immune-oncology pipeline over the last years. This is in great part due to the recent …

The focus of cancer treatment has recently shifted toward targeted therapies, including
immunotherapy, which allow better individualization of care and are hoped to increase the …

Simple Summary Chimeric antigen receptors (CAR) are engineered molecules expressed
on the cell surface that can recognise specific proteins and deliver an activation signal to the …

T cells play a key role in cell-mediated immunity, and strategies to genetically modify T cells,
including chimeric antigen receptor (CAR) T cell therapy and T cell receptor (TCR) T cell …

T cells genetically engineered to express chimeric antigen receptors (CARs) have proven—
and impressive—therapeutic activity in patients with certain subtypes of B cell leukaemia or …

Over the last decade, the emergence of several novel therapeutic approaches has changed
the therapeutic perspective of human malignancies. Adoptive immunotherapy through …

Highlights•The CD19 paradigm has established CARs as a novel immunotherapy in
oncology.•The synthetic tool box is not limited to CARs and includes CCRs, iCARs and …

CD4+ and CD8+ T lymphocytes are powerful components of adaptive immunity, which
essentially contribute to the elimination of tumors. Due to their cytotoxic capacity, T cells …