Neonatal cholestasis: emerging molecular diagnostics and potential novel therapeutics

AG Feldman, RJ Sokol - Nature reviews Gastroenterology & hepatology, 2019 - nature.com
Neonatal cholestasis is a group of rare disorders of impaired bile flow characterized by
conjugated hyperbilirubinaemia in the newborn and young infant. Neonatal cholestasis is …

Recent developments in diagnostics and treatment of neonatal cholestasis

AG Feldman, RJ Sokol - Seminars in pediatric surgery, 2020 - Elsevier
Neonatal cholestasis is characterized by conjugated hyperbilirubinemia in the newborn and
young infant and is a sign common to over 100 hepatobiliary and/or metabolic disorders. A …

Neonatal cholestasis: Updates on diagnostics, therapeutics, and prevention

AG Feldman, RJ Sokol - Neoreviews, 2021 - publications.aap.org
Cholestatic jaundice is a common presenting feature of hepatobiliary and/or metabolic
dysfunction in the newborn and young infant. Timely detection of cholestasis, followed by …

Neonatal cholestasis–differential diagnoses, current diagnostic procedures, and treatment

T Götze, H Blessing, C Grillhösl, P Gerner… - Frontiers in …, 2015 - frontiersin.org
Cholestatic jaundice in early infancy is a complex diagnostic problem. Misdiagnosis of
cholestasis as physiologic jaundice delays the identification of severe liver diseases. In the …

Biliary atresia and other cholestatic childhood diseases: advances and future challenges

HJ Verkade, JA Bezerra, M Davenport… - Journal of …, 2016 - Elsevier
Biliary Atresia and other cholestatic childhood diseases are rare conditions affecting the
function and/or anatomy along the canalicular-bile duct continuum, characterised by onset of …

Diversity of disorders causing neonatal cholestasis–the experience of a tertiary pediatric center in Germany

A Hoerning, S Raub, A Dechêne, MN Brosch… - Frontiers in …, 2014 - frontiersin.org
Background and Objective: Rapidly establishing the cause of neonatal cholestasis is an
urgent matter. The aim of this study was to report on the prevalence and mortality of the …

Pathogenesis and outcome of biliary atresia: current concepts

RJ Sokol, C Mack, MR Narkewicz… - Journal of pediatric …, 2003 - journals.lww.com
Neonatal cholestatic disorders are a group of hepatobiliary diseases occurring within the
first 3 months of life. Bile flow is impaired, and patients have conjugated hyperbilirubinemia …

Neonatal cholestasis

WF Balistreri - The Journal of pediatrics, 1985 - Elsevier
THE HETEROGENEOUS NATURE of the diseases that have neonatal cholestasis
(prOlonged conjugated hyperbilirubinemia) as the initial manifestation creates challenges in …

Neonatal cholestasis

AG Feldman, RJ Sokol - Neoreviews, 2013 - publications.aap.org
Cholestatic jaundice is a common presenting feature of neonatal hepatobiliary and
metabolic dysfunction. Any infant who remains jaundiced beyond age 2 to 3 weeks should …

Cholestasis in the newborn and infant

B Fischler, T Lamireau - Clinics and research in hepatology and …, 2014 - Elsevier
Neonatal cholestasis occurs in approximately 1 in 2500 term infants, the most common
underlying disease being biliary atresia, viral infections and α 1-antitrypsin deficiency. The …