Large‐scale clinical trials have demonstrated that metabolic control achieved early in the
course of diabetes substantially reduces development and progression of diabetes and the …

Prevention of long-term complications remains the main challenge in the treatment of
diabetes. A strong relationship between glucose control and development of complications …

Large randomized studies have established that early intensive glycaemic control reduces
the risk of diabetic complications, both micro-and macrovascular. However, epidemiological …

Chronic hyperglycemia of diabetes leads to microvascular complications that severely
impact quality of life. Diabetic retinopathy (DR) may be the most common of these and is a …

Large randomized studies have established that early intensive glycaemic control reduces
the risk of diabetic complications, both micro and macrovascular. However, epidemiological …

Multiple and complex pathways promote the deleterious effects of hyperglycemia in
diabetes, ultimately leading to micro-and macrovascular disease. Some of the known …

Context: The concept of a “metabolic memory,” that is of diabetic vascular stresses persisting
after glucose normalization, has been supported both in the laboratory and in the clinic and …

Diabetes mellitus (DM) exhibits raised prevalence worldwide. There is a large body of
evidence regarding the incidence of DM closely associates with cardiovascular (CV) …

The relationships of glycemic control over time with the development of complications have
been investigated in several studies, but new areas of debate continue to arise. Does …

Large randomized studies have established that early intensive glycemic control reduces
the risk of diabetic complications, both micro and macrovascular. However, epidemiological …