Behind only Alzheimer's disease, vascular contributions to cognitive impairment and
dementia (VCID) is the second most common cause of dementia, affecting roughly 10–40 …

Homocysteine is produced physiologically in all cells, and is present in plasma of healthy
individuals (plasma [HCy]: 3–10 μM). While rare genetic mutations (CBS, MTHFR) cause …

A high serum level of homocysteine, known as hyperhomocystenemia (HHcy) is associated
with vascular dysfunction such as altered angiogenesis and increased membrane …

There is strong evidence that homocysteine is a risk factor not only for cerebrovascular
diseases but also for degenerative dementias. A recent consensus statement renewed the …

Homocysteine (Hcy) is a key junction in methionine metabolism. In inherited forms of
hyperhomocysteinemia patients develop early vascular damage and cognitive decline …

Homocysteine (Hcy) is known to increase the risk of cerebrovascular disease (CVD). Recent
evidence suggests its direct contribution to brain atrophy, cognitive impairment and possibly …

There is some evidence from recent observational studies that hyperhomocysteinemia is a
risk factor for cognitive dysfunction, including Alzheimer's disease and vascular dementia …

Elevated plasma total homocysteine is associated with increased risk of
dementia/Alzheimer's disease, but underlying pathophysiological mechanisms are not fully …

Background: Homocysteine has been identified as a potential risk factor for stroke, cerebral
small-vessel diseases (SVD), and dementia. Objective: The present study aimed to …

Obective: High homocysteine (Hct) has been causatively linked to Alzheimer disease (AD)
and vascular dementia (VaD) in old age, but research methodologies and outcome …