IL-7 and lymphopenia
Interleukin-7 (IL-7) is a growth and anti-apoptotic factor for T-lymphocytes, with potential for
clinical use in the treatment of immunodeficiencies due to loss of T-cells. Lymphopenia …
clinical use in the treatment of immunodeficiencies due to loss of T-cells. Lymphopenia …
Interleukin-7 (IL-7): immune function, involvement in the pathogenesis of HIV infection and therapeutic potential
S Beq, JF Delfraissy, J Theze - European Cytokine Network, 2004 - jle.com
Interleukin 7 (IL-7), which is constitutively produced particularly by stromal cells from the
bone marrow and thymus, plays a crucial role in T cell homeostasis. This cytokine is …
bone marrow and thymus, plays a crucial role in T cell homeostasis. This cytokine is …
IL-7: comprehensive review
Overview IL-7 is a member of the family of cytokines with four anti-parallel α helixes that bind
Type I cytokine receptors. It is produced by stromal cells and is required for development …
Type I cytokine receptors. It is produced by stromal cells and is required for development …
IL-7 administration to humans leads to expansion of CD8+ and CD4+ cells but a relative decrease of CD4+ T-regulatory cells
SA Rosenberg, C Sportès, M Ahmadzadeh… - Journal of …, 2006 - journals.lww.com
Lymphopenia is a serious consequence of HIV infection and the administration of cancer
chemotherapeutic agents. Although growth factors can be administered to patients to …
chemotherapeutic agents. Although growth factors can be administered to patients to …
The many faces of IL-7: from lymphopoiesis to peripheral T cell maintenance
TJ Fry, CL Mackall - The Journal of Immunology, 2005 - journals.aai.org
IL-7 is well known as a lymphopoietic cytokine, but recent studies have also identified a
critical role for IL-7 in peripheral T cell homeostasis. IL-7 is well poised to serve as a …
critical role for IL-7 in peripheral T cell homeostasis. IL-7 is well poised to serve as a …
Interleukin-7: from bench to clinic
TJ Fry, CL Mackall - Blood, The Journal of the American Society …, 2002 - ashpublications.org
Interleukin-7 (IL-7) was initially isolated more than 10 years ago. 1-4 Nevertheless, the
complete set of physiologic roles for this cytokine, especially those involving lymphocyte …
complete set of physiologic roles for this cytokine, especially those involving lymphocyte …
The IL-7/IL-7 receptor axis: understanding its central role in T-cell homeostasis and the challenges facing its utilization as a novel therapy
Interleukin-7 (IL-7) is a cytokine produced predominantly by stromal cells of the thymus and
bone marrow and is essential for lymphopoiesis. This paper reviews the importance of IL-7 …
bone marrow and is essential for lymphopoiesis. This paper reviews the importance of IL-7 …
Harnessing the biology of IL-7 for therapeutic application
CL Mackall, TJ Fry, RE Gress - Nature Reviews Immunology, 2011 - nature.com
Abstract Interleukin-7 (IL-7) is required for T cell development and for maintaining and
restoring homeostasis of mature T cells. IL-7 is a limiting resource under normal conditions …
restoring homeostasis of mature T cells. IL-7 is a limiting resource under normal conditions …
A potential role for interleukin-7 in T-cell homeostasis
TJ Fry, E Connick, J Falloon… - Blood, The Journal …, 2001 - ashpublications.org
Abstract Interleukin (IL)-7 is known to up-regulate thymopoietic pathways of T-cell
regeneration. Recent work also has shown it to potently enhance thymic-independent …
regeneration. Recent work also has shown it to potently enhance thymic-independent …
An overview of IL-7 biology and its use in immunotherapy
N ElKassar, RE Gress - Journal of immunotoxicology, 2010 - Taylor & Francis
Interleukin (IL)-7 is required for T-cell development as well as for the survival and
homeostasis of mature T-cells. In the thymus, the double negative (DN) CD4− CD8 …
homeostasis of mature T-cells. In the thymus, the double negative (DN) CD4− CD8 …