[HTML][HTML] The distinction of CPR bacteria from other bacteria based on protein family content

R Méheust, D Burstein, CJ Castelle… - Nature communications, 2019 - nature.com
Candidate phyla radiation (CPR) bacteria separate phylogenetically from other bacteria, but
the organismal distribution of their protein families remains unclear. Here, we leveraged …

Biosynthetic capacity, metabolic variety and unusual biology in the CPR and DPANN radiations

CJ Castelle, CT Brown, K Anantharaman… - Nature Reviews …, 2018 - nature.com
Candidate phyla radiation (CPR) bacteria and DPANN (an acronym of the names of the first
included phyla) archaea are massive radiations of organisms that are widely distributed …

Unifying the known and unknown microbial coding sequence space

C Vanni, MS Schechter, SG Acinas, A Barberán… - Elife, 2022 - elifesciences.org
Genes of unknown function are among the biggest challenges in molecular biology,
especially in microbial systems, where 40–60% of the predicted genes are unknown …

[HTML][HTML] The rise of diversity in metabolic platforms across the Candidate Phyla Radiation

AL Jaffe, CJ Castelle, PB Matheus Carnevali… - BMC biology, 2020 - Springer
Background A unifying feature of the bacterial Candidate Phyla Radiation (CPR) is a limited
and highly variable repertoire of biosynthetic capabilities. However, the distribution of …

Unusual biology across a group comprising more than 15% of domain Bacteria

CT Brown, LA Hug, BC Thomas, I Sharon, CJ Castelle… - Nature, 2015 - nature.com
A prominent feature of the bacterial domain is a radiation of major lineages that are defined
as candidate phyla because they lack isolated representatives. Bacteria from these phyla …

[HTML][HTML] Unusual respiratory capacity and nitrogen metabolism in a Parcubacterium (OD1) of the Candidate Phyla Radiation

CJ Castelle, CT Brown, BC Thomas, KH Williams… - Scientific reports, 2017 - nature.com
Abstract The Candidate Phyla Radiation (CPR) is a large group of bacteria, the scale of
which approaches that of all other bacteria. CPR organisms are inferred to depend on other …

[HTML][HTML] Members of the Candidate Phyla Radiation are functionally differentiated by carbon-and nitrogen-cycling capabilities

RE Danczak, MD Johnston, C Kenah, M Slattery… - Microbiome, 2017 - Springer
Abstract Background The Candidate Phyla Radiation (CPR) is a recently described
expansion of the tree of life that represents more than 15% of all bacterial diversity and …

[HTML][HTML] Major new microbial groups expand diversity and alter our understanding of the tree of life

CJ Castelle, JF Banfield - Cell, 2018 - cell.com
The recent recovery of genomes for organisms from phyla with no isolated representative
(candidate phyla) via cultivation-independent genomics enabled delineation of major new …

Retroelement-guided protein diversification abounds in vast lineages of Bacteria and Archaea

BG Paul, D Burstein, CJ Castelle, S Handa… - Nature …, 2017 - nature.com
Major radiations of enigmatic Bacteria and Archaea with large inventories of
uncharacterized proteins are a striking feature of the Tree of Life 1–5. The processes that led …

[HTML][HTML] Genetic manipulation of Patescibacteria provides mechanistic insights into microbial dark matter and the epibiotic lifestyle

Y Wang, LA Gallagher, PA Andrade, A Liu… - Cell, 2023 - cell.com
Patescibacteria, also known as the candidate phyla radiation (CPR), are a diverse group of
bacteria that constitute a disproportionately large fraction of microbial dark matter. Its few …