The role of flavonoids as a cardioprotective strategy against doxorubicin-induced cardiotoxicity: a review

RA Syahputra, U Harahap, A Dalimunthe, MP Nasution… - Molecules, 2022 - mdpi.com
Doxorubicin is a widely used and promising anticancer drug; however, a severe dose-
dependent cardiotoxicity hampers its therapeutic value. Doxorubicin may cause acute and …

Recent progress in doxorubicin-induced cardiotoxicity and protective potential of natural products

J Yu, C Wang, Q Kong, X Wu, JJ Lu, X Chen - Phytomedicine, 2018 - Elsevier
Background As an anthracycline antibiotic, doxorubicin (DOX) is one of the most potent and
widely used chemotherapeutic agents for various types of solid tumors. Unfortunately …

The protective role of phenolic compounds against doxorubicin-induced cardiotoxicity: a comprehensive review

K Razavi-Azarkhiavi, M Iranshahy, A Sahebkar… - Nutrition and …, 2016 - Taylor & Francis
Although doxorubicin (DOX) is among the most widely used anticancer agents, its clinical
application is hampered owing to its cardiotoxicity. Adjuvant therapy with an antioxidant has …

Doxorubicin-induced cardiotoxicity: an overview on pre-clinical therapeutic approaches

M Sheibani, Y Azizi, M Shayan… - Cardiovascular …, 2022 - Springer
Doxorubicin is an effective chemotherapeutic agent prescribed to treat solid tumors (eg,
ovary, breast, and gastrointestinal cancers). This anti-cancer drug has various side effects …

Cardioprotective mechanisms of phytochemicals against doxorubicin-induced cardiotoxicity

AI Abushouk, A Ismail, AMA Salem, AM Afifi… - Biomedicine & …, 2017 - Elsevier
Doxorubicin (DOX) is an anthracycline antibiotic, which is effectively used in the treatment of
different malignancies, such as leukemias and lymphomas. Its most serious side effect is …

Cardioprotective potentials of plant‐derived small molecules against doxorubicin associated cardiotoxicity

S Ojha, H Al Taee, S Goyal, UB Mahajan… - Oxidative medicine …, 2016 - Wiley Online Library
Doxorubicin (DOX) is a potent and widely used anthracycline antibiotic for the treatment of
several malignancies. Unfortunately, the clinical utility of DOX is often restricted due to the …

Resveratrol, a polyphenol phytoalexin, protects against doxorubicin‐induced cardiotoxicity

J Gu, W Hu, D Zhang - Journal of cellular and molecular …, 2015 - Wiley Online Library
Doxorubicin is the mainstay of treatment for various haematological malignancies and solid
tumours. However, its clinical application may be hampered by dose‐dependent …

Kaempferol protects against doxorubicin-induced cardiotoxicity in vivo and in vitro

J Xiao, GB Sun, B Sun, Y Wu, L He, X Wang, RC Chen… - Toxicology, 2012 - Elsevier
The long-term clinical usefulness of doxorubicin (DOX), an anthracycline with potent
antitumor activity, is limited by DOX-induced cardiotoxicity. Kaempferol, one of the most …

Polyphenols, autophagy and doxorubicin-induced cardiotoxicity

S Shabalala, CJF Muller, J Louw, R Johnson - Life sciences, 2017 - Elsevier
Doxorubicin is a highly effective, first line chemotherapeutic agent used in the management
of hematological and solid tumors. The effective use of doxorubicin in cancer therapy has …

[PDF][PDF] Doxorubicin-induced cardiotoxicity: molecular mechanism and protection by conventional drugs and natural products

HM Alkuraishy, AI Al-Gareeb… - Int J Clin Oncol Cancer …, 2017 - academia.edu
Doxorubicin is useful anticancer drug because it's used in treatment of acute leukemia,
Hodgkin's and non-Hodgkin's lymphomas, and many other malignant neoplasm. The …