Medications such as Vioxx and procedures such as vertebroplasty for back pain are among
the medical" advances" that turned out to be dangerous or useless. What Dr. Vinayak K …

Medical reversal occurs when a new clinical trial—superior to predecessors by virtue of
better controls, design, size, or endpoints—contradicts current clinical practice. In recent …

IDEALLY, GOOD MEDICAL PRACTICES ARE REPLACED BY BET-ter ones, based on
robust comparative trials in which new interventions outperform older ones and establish …

The ability to identify medical reversals and other low-value medical practices is an essential
prerequisite for efforts to reduce spending on such practices. Through an analysis of more …

Objective To identify medical practices that offer no net benefits. Methods We reviewed all
original articles published in 10 years (2001-2010) in one high-impact journal. Articles were …

The 21st Century Cures Act — A View from the NIH | NEJM Skip to main content NEJM Group
Follow Us Facebook Twitter Instagram YouTube LinkedIn Prepare to become a physician …

The careful national survey reported by Eisenberg et al. in this issue of the Journal1 tells us
that in a given year about a third of all American adults use unconventional medical …

Annotation Medical science has always promised--and often delivered--a longer, better life.
But as the pace of science accelerates, do our expectations become unreasonable, fueled …

“... Above all do no harm” launches a career in medicine and throughout their career
compels the physician to act in the patient's best interest. It can be said that the potential for …

There is a spectrum of innovation in clinical practice. At one end are minor changes that are
inherent and appropriate in individual practice. At the other are innovations that are allowed …