Orbitrap mass spectrometry in full scan mode enables the simultaneous detection of
hundreds of metabolites and their isotope-labeled forms. Yet, sensitivity remains limiting for …

Orbitrap mass spectrometry in full scan mode enables the simultaneous detection of
hundreds of metabolites and their isotope-labeled forms. Yet, sensitivity remains limiting for …

Orbitraps are high-resolution ion-trap mass spectrometers that are widely used in
metabolomics. While the mass accuracy and resolving power of orbitraps have been …

Annotation of signals of interest represents a key point in mass spectrometry-based
metabolomics studies. The first level of investigation is the elemental composition, which can …

Secondary electrospray ionization high-resolution mass spectrometry (SESI-HRMS) is an
emerging technique for the detection of volatile metabolites. However, sensitivity and …

Modern separation methods in conjunction with high-resolution accurate mass (HRAM)
spectrometry can provide an enormous number of features characterized by exact mass and …

Chemical isotope labeling liquid chromatography-mass spectrometry (CIL LC-MS) is a
powerful technique in metabolomics, offering extensive coverage of the metabolome. This …

Mass spectrometry based metabolomics is a widely used approach in biomedical research.
However, current methods coupling mass spectrometry with chromatography are time …

Identification of unknown peaks in gas chromatography/mass spectrometry (GC/MS)-based
discovery metabolomics is challenging, and remains necessary to permit discovery of novel …

The annotation and identification of metabolites is a current bottleneck in non-targeted
metabolomics studies. Although accurate measurement of m/z is applied routinely in UPLC …