Huntington disease
Huntington disease is devastating to patients and their families—with autosomal dominant
inheritance, onset typically in the prime of adult life, progressive course, and a combination …
inheritance, onset typically in the prime of adult life, progressive course, and a combination …
Huntington disease
R Ghosh, SJ Tabrizi - Handbook of clinical neurology, 2018 - Elsevier
Huntington disease is a monogenic neurodegenerative disorder that displays an autosomal-
dominant pattern of inheritance. It is characterized by motor, psychiatric, and cognitive …
dominant pattern of inheritance. It is characterized by motor, psychiatric, and cognitive …
Huntington disease: a quarter century of progress since the gene discovery
CM Testa, J Jankovic - Journal of the neurological sciences, 2019 - Elsevier
Huntington disease (HD) is an autosomal dominant neurodegenerative disorder
characterized by motor, behavioral, and cognitive manifestations. It is caused by an …
characterized by motor, behavioral, and cognitive manifestations. It is caused by an …
Huntington disease: natural history, biomarkers and prospects for therapeutics
CA Ross, EH Aylward, EJ Wild, DR Langbehn… - Nature Reviews …, 2014 - nature.com
Huntington disease (HD) can be seen as a model neurodegenerative disorder, in that it is
caused by a single genetic mutation and is amenable to predictive genetic testing, with …
caused by a single genetic mutation and is amenable to predictive genetic testing, with …
Huntington disease: pathogenesis and treatment
P Dayalu, RL Albin - Neurologic clinics, 2015 - neurologic.theclinics.com
Huntington disease (HD) is an autosomal dominant inherited neurodegenerative disease
characterized by progressive motor, behavioral, and cognitive decline, resulting in death …
characterized by progressive motor, behavioral, and cognitive decline, resulting in death …
Genetics and neuropathology of Huntington's disease
A Reiner, I Dragatsis, P Dietrich - International review of neurobiology, 2011 - Elsevier
Huntington's disease (HD) is an autosomal dominant progressive neurodegenerative
disorder that prominently affects the basal ganglia, leading to affective, cognitive, behavioral …
disorder that prominently affects the basal ganglia, leading to affective, cognitive, behavioral …
Huntington's disease: a clinical review
P McColgan, SJ Tabrizi - European journal of neurology, 2018 - Wiley Online Library
Huntington's disease (HD) is a fully penetrant neurodegenerative disease caused by a
dominantly inherited CAG trinucleotide repeat expansion in the huntingtin gene on …
dominantly inherited CAG trinucleotide repeat expansion in the huntingtin gene on …
Huntington's disease: from pathology and genetics to potential therapies
S Imarisio, J Carmichael, V Korolchuk… - Biochemical …, 2008 - portlandpress.com
Huntington's disease (HD) is a devastating autosomal dominant neurodegenerative disease
caused by a CAG trinucleotide repeat expansion encoding an abnormally long …
caused by a CAG trinucleotide repeat expansion encoding an abnormally long …
Huntington's disease: mechanisms of pathogenesis and therapeutic strategies
M Jimenez-Sanchez, F Licitra… - Cold Spring …, 2017 - perspectivesinmedicine.cshlp.org
Huntington's disease is a late-onset neurodegenerative disease caused by a CAG
trinucleotide repeat in the gene encoding the huntingtin protein. Despite its well-defined …
trinucleotide repeat in the gene encoding the huntingtin protein. Despite its well-defined …
Genetics of Huntington disease
MA Nance - Handbook of clinical neurology, 2017 - Elsevier
In this chapter, we review the evolution of our understanding of the genetic aspects of HD,
and the applications of our understanding in the management of Huntington's disease …
and the applications of our understanding in the management of Huntington's disease …