Huntington disease is devastating to patients and their families—with autosomal dominant
inheritance, onset typically in the prime of adult life, progressive course, and a combination …

Huntington disease is a monogenic neurodegenerative disorder that displays an autosomal-
dominant pattern of inheritance. It is characterized by motor, psychiatric, and cognitive …

Huntington disease (HD) is an autosomal dominant neurodegenerative disorder
characterized by motor, behavioral, and cognitive manifestations. It is caused by an …

Huntington disease (HD) can be seen as a model neurodegenerative disorder, in that it is
caused by a single genetic mutation and is amenable to predictive genetic testing, with …

Huntington disease (HD) is an autosomal dominant inherited neurodegenerative disease
characterized by progressive motor, behavioral, and cognitive decline, resulting in death …

Huntington's disease (HD) is an autosomal dominant progressive neurodegenerative
disorder that prominently affects the basal ganglia, leading to affective, cognitive, behavioral …

Huntington's disease (HD) is a fully penetrant neurodegenerative disease caused by a
dominantly inherited CAG trinucleotide repeat expansion in the huntingtin gene on …

Huntington's disease (HD) is a devastating autosomal dominant neurodegenerative disease
caused by a CAG trinucleotide repeat expansion encoding an abnormally long …

Huntington's disease is a late-onset neurodegenerative disease caused by a CAG
trinucleotide repeat in the gene encoding the huntingtin protein. Despite its well-defined …

In this chapter, we review the evolution of our understanding of the genetic aspects of HD,
and the applications of our understanding in the management of Huntington's disease …