Advanced age is associated with a decline in cognitive function, likely caused by a
combination of modifiable and non-modifiable factors such as genetics and lifestyle choices …

Humanin is a member of a new family of peptides that are encoded by short open reading
frames within the mitochondrial genome. It is conserved in animals and is both …

Humanin is a small secreted peptide that is encoded in the mitochondrial genome. Humanin
and its analogues have a protective role in multiple age-related diseases including type 2 …

Simple Summary Humanin is a small mitochondrial-derived peptide still under study, with a
number of potential therapeutic applications for various age-related diseases. It plays an …

Background Alzheimer's disease (AD), Parkinson's disease (PD), and age-related macular
degeneration (AMD) are common among neurodegenerative diseases, but investigations …

Aging is influenced by endocrine pathways including the growth hormone/insulin‐like
growth factor‐1 (GH/IGF) axis. Mitochondrial function has also been linked to the aging …

Abstract Mitochondrial-derived peptides (MDPs), encoded by mitochondrial DNA, play a
cytoprotective role by helping preserve mitochondrial function and cell viability under …

Humanin (HN) is 24-amino acid mitochondria-associated peptide. Since its initial discovery
over a decade ago, a role for HN has been reported in many biological processes such as …

A decline in mitochondrial quality and activity has been associated with normal aging and
correlated with the development of a wide range of age-related diseases. Here, we review …

Astroglial cells are crucial for central nervous system (CNS) homeostasis. They undergo
complex morpho-functional changes during aging and in response to hormonal milieu …