MAP/ERK signaling in developing cognitive and emotional function and its effect on pathological and neurodegenerative processes

H Albert-Gascó, F Ros-Bernal… - International journal of …, 2020 - mdpi.com
The signaling pathway of the microtubule-associated protein kinase or extracellular
regulated kinase (MAPK/ERK) is a common mechanism of extracellular information …

ERK/MAPK signalling in the developing brain: Perturbations and consequences

JD Iroegbu, OK Ijomone, OM Femi-Akinlosotu… - Neuroscience & …, 2021 - Elsevier
The extracellular regulated kinase/microtubule-associated protein kinase (ERK/MAPK)
signalling pathway transduces signals that cause an alteration in the ongoing metabolic …

ERK in learning and memory: a review of recent research

S Peng, Y Zhang, J Zhang, H Wang, B Ren - International journal of …, 2010 - mdpi.com
The extracellular signal-regulated kinase (ERK) pathway is a member of the mitogen-
activated protein kinase (MAPK) superfamily, which is an important, highly conserved family …

Disrupted ERK signaling during cortical development leads to abnormal progenitor proliferation, neuronal and network excitability and behavior, modeling human …

J Pucilowska, PA Puzerey, JC Karlo… - Journal of …, 2012 - Soc Neuroscience
Genetic disorders arising from copy number variations in the ERK (extracellular signal-
regulated kinase) MAP (mitogen-activated protein) kinases or mutations in their upstream …

[HTML][HTML] MAP'ing CNS development and cognition: an ERKsome process

IS Samuels, SC Saitta, GE Landreth - Neuron, 2009 - cell.com
The ERK MAP kinase signaling cascade plays critical roles in brain development, learning,
memory, and cognition. It has recently been appreciated that mutation or deletion of …

The extracellular signal-regulated kinase 1/2 pathway in neurological diseases: A potential therapeutic target

J Sun, G Nan - International journal of molecular …, 2017 - spandidos-publications.com
Signaling pathways are critical modulators of a variety of physiological and pathological
processes, and the abnormal activation of some signaling pathways can contribute to …

The role of ERK1/2 in the regulation of proliferation and differentiation of astrocytes in developing brain

P Cheng, I Alberts, X Li - International Journal of Developmental …, 2013 - Elsevier
Extracellular signal regulated kinases (ERK) are important components of the Ras-Raf-MEK-
ERK signaling pathway cascades that mediate intracellular stimuli transduction and gene …

Role of MAP kinase in neurons

K Fukunaga, E Miyamoto - Molecular neurobiology, 1998 - Springer
Extracellular stimuli such as neurotransmitters, neurotrophins, and growth factors in the
brain regulate critical cellular events, including synaptic transmission, neuronal plasticity …

Molecular psychology: roles for the ERK MAP kinase cascade in memory

JP Adams, JD Sweatt - Annual review of pharmacology and …, 2002 - annualreviews.org
In this review we describe an emerging understanding of the roles of the Extracellular-signal
regulated kinase/mitogen-activated protein kinase (ERK/MAPK) cascade in learning and …

Mice lacking the ERK1 isoform of MAP kinase are unimpaired in emotional learning

JC Selcher, T Nekrasova, R Paylor… - Learning & …, 2001 - learnmem.cshlp.org
The extracellular signal-regulated kinases (ERKs) are members of the mitogen-activated
protein kinase (MAPK) superfamily of enzymes and have recently garnered considerable …