Parecoxib inhibits tumorigenesis and angiogenesis in hepatocellular carcinoma through ERK–VEGF/MMPs signaling pathway

L Tian, YQ Huang, Y Liu, JW Liu, Y Liu - IUBMB life - Wiley Online Library
Parecoxib, a well‐recognized nonsteroidal anti‐inflammatory drug, has been reported to
possess anticancer properties in various tumor types. In this work, we aimed to investigate …

RETRACTED ARTICLE: Parecoxib inhibits esophageal squamous cell carcinoma progression via the PDK1–AKT pathway

HM Huang, XY Huang, SP Wu, CK Chen… - Cellular & molecular …, 2022 - Springer
Background Parecoxib plays an important role in inhibition of human cancer. However, the
effect of parecoxib on esophageal squamous cell carcinoma (ESCC) is still not well known …

Celecoxib attenuates hepatocellular proliferative capacity during hepatocarcinogenesis by modulating a PTEN/NF-κB/PRL-3 pathway

C Zhang, J Zhou, J Hu, S Lei, M Yuan, L Chen… - RSC …, 2019 - pubs.rsc.org
Although the efficacy of celecoxib on various cancer cell behaviors, including aberrant
proliferation, in cultured hepatocellular carcinoma (HCC) cells has been demonstrated …

In vitro and In vivo Effects and Mechanisms of Celecoxib-Induced Growth Inhibition of Human Hepatocellular Carcinoma Cells

W Cui, CH Yu, KQ Hu - Clinical cancer research, 2005 - AACR
Abstract Purpose: Cyclooxygenase-2 (COX-2) inhibitors cause growth inhibition of human
hepatocellular carcinoma cells but it remains unclear whether this is both COX-2 dependent …

Celecoxib inhibits cancer growth through cyclooxygenase 2 (COX2) independent pathways in HepG2 hepatocellular carcinoma

S Khlefat - Jordan Journal of Pharmaceutical Sciences, 2021 - archives.ju.edu.jo
Chronic inflammation has long been associated to carcinogenesis. Evidence has shown that
nonsteroidal anti-inflammatory drugs (NSAIDs) may decrease the risk of certain types of …

[HTML][HTML] Celecoxib suppresses hepatoma stemness and progression by up-regulating PTEN

TH Chu, HH Chan, HM Kuo, LF Liu, TH Hu, CK Sun… - Oncotarget, 2014 - ncbi.nlm.nih.gov
Celecoxib, a COX-2 inhibitor and non-steroidal anti-inflammatory drug, can prevent several
types of cancer, including hepatocellular carcinoma (HCC). Here we show that celecoxib …

Celecoxib alleviates AKT/c‐Met‐triggered rapid hepatocarcinogenesis by suppressing a novel COX‐2/AKT/FASN cascade

Z Qiu, C Zhang, J Zhou, J Hu, L Sheng… - Molecular …, 2019 - Wiley Online Library
Previous studies have demonstrated that the selective cyclooxygenase‐2 (COX‐2) inhibitor
celecoxib shows efficacy against multiple cancers, including hepatocellular carcinoma …

Parecoxib expresses anti‐metastasis effect through inhibition of epithelial‐mesenchymal transition and the Wnt/β‐catenin signaling pathway in human colon cancer …

CH Wong, WL Chang, FJ Lu, YW Liu… - Environmental …, 2022 - Wiley Online Library
Colorectal cancer is the third leading cause of cancer death in Taiwan. Current treatments
involve combination of surgical resection, radiation, and chemotherapy. These treatments …

[HTML][HTML] Celecoxib inhibits hepatocellular carcinoma cell growth and migration by targeting PNO1

H Dai, S Zhang, R Ma, L Pan - Medical Science Monitor …, 2019 - ncbi.nlm.nih.gov
Celecoxib Inhibits Hepatocellular Carcinoma Cell Growth and Migration by Targeting PNO1 -
PMC Back to Top Skip to main content NIH NLM Logo Access keys NCBI Homepage MyNCBI …

Elucidating the mechanisms of action of parecoxib in the MG-63 osteosarcoma cell line

S Lemos, B Sampaio-Marques, P Ludovico… - Anti-Cancer …, 2020 - journals.lww.com
Different types of tumors often present an overexpression of cyclooxygenase-2. The aim of
this study was to evaluate the effects of parecoxib (NSAID, cyclooxygenase-2 selective …