Prolonged use of an antineoplastic agent methotrexate (MTX), can cause numerous side
effects such as nephrotoxicity. The aim of this study was to examine the effects of MTX on …

Aim. Methotrexate (MTX), a folic acid antagonist, is one of the chemotherapeutic agents
widely used in the treatment of some types of cancers. Nephrotoxicity is one of the …

Background: Nephrotoxicity is one of the adverse side effects of methotrexate (MTX)
chemotherapy. The mechanism of renotoxicity of MTX is not fully understood. It is essential …

Objective: This experimental study was conducted to elucidate the possible
protective/therapeutic effects of quercetin against methotrexate (Mtx)-induced kidney toxicity …

The aim of the current study was to investigate the probable protective effects of
Pentoxifylline (PTX) and Alpha Lipoic Acid (ALA), which display anti-oxidative efficacy …

Materials and Methods: Forty five male Wis-tar rats were assigned to 3 groups of 15 animals
each: Group 1: control group (0.9% saline). Group 2: MTX; injected with 20 mg/kg MTX …

Background: Methotrexate, as a chemotherapy drug, can cause chronic liver damage and
oxidative stress. Aim of this study was to evaluate the preventive effect of gallic acid (GA) on …

Background Methotrexate (MTX) is an efficacious anticancer agent constrained in clinical
use due to its toxicity on non-targeted tissue, a considerable source of worry to clinicians …

The exact mechanisms of methotrexate-induced renal toxicity have not yet been determined.
However, several hypotheses have been put forward, including oxidative stress. The aim of …

Background/aim: Methotrexate (MTX) has been widely used for treatment of cancer and
rheumatoid arthritis, but its use has been limited by its nephrotoxicity. This study was carried …