Calcitonin gene‐related peptide (CGRP) is a key mediator in primary headaches including
migraine. Animal models of meningeal nociception demonstrate both peripheral and central …

Primary headaches such as migraine are postulated to involve the activation of sensory
trigeminal pain neurons that innervate intracranial blood vessels and the dura mater. It is …

Calcitonin gene-related peptide (CGRP) is a potent vasodilator and a neuromodulator
implicated in the pathophysiology of migraine. It binds to the extracellular domains of …

Functional imaging studies have revealed that certain brainstem areas are activated during
migraine attacks. The neuropeptide calcitonin gene–related peptide (CGRP) is associated …

Calcitonin gene related peptide (CGRP) has a key role in migraine and recently CGRP
receptor antagonists have demonstrated clinical efficacy in the treatment of migraine …

Background Calcitonin gene-related peptide (CGRP) has a key role in migraine
pathophysiology and is associated with activation of the trigeminovascular system. The …

Objective The trigeminovascular system plays a central role in migraine, a condition in need
of new treatments. The neuropeptide, calcitonin gene‐related peptide (CGRP), is proposed …

Clinical and experimental results have revealed a fundamental role of calcitonin gene-
related peptide (CGRP) in primary headaches. CGRP is widely expressed in neurons both …

Calcitonin gene–related peptide (CGRP) is a 37-amino acid peptide found primarily in the C
and Aδ sensory fibers arising from the dorsal root and trigeminal ganglia, as well as the …

The neuropeptide calcitonin gene-related peptide (CGRP) from the trigeminal ganglion has
been established as a key player in the pathogenesis of migraine. In this study, we provide …