A chemoselective Dieckmann ring closure using an oxazolidine derived from serine may be
used to generate a tetramic acid, the further manipulation of which by reduction and ring …

A chemoselective route which provides direct access to bicyclic tetramates, making use of
Dieckmann cyclisation of functionalised oxazolidines and imidazolidines derived from an …

A new method has been developed for regiospecific conversion of substituted anilines to
isatins. The method utilizes the reaction of an ortho-lithiated, protected aniline derivative with …

Microbial infection is one of the major concerns for human health in the modern era.
Condition is further worsening due to the development of resistance by the microbe against …

The asymmetric total synthesis of (+)-isatisine A has been accomplished commencing with a
Lewis acid-catalyzed cyclization of homochiral (S)-vinylcyclopropane diester and N …

A series of 5-haloisatins were aminomethylated in position 1 and hydrazino groups were
introduced in position 3. Synthesized N-Mannich bases and hydrazones were biologically …

Isatin (1H-indole-2, 3-dione, Figure 1) was first obtained by Erdman and Laurent in 1841 as
a product from the oxidation of indigo by nitric and chromic acids. 1 Since then, isatin and its …

A general route, which provides direct access to substituted bicyclic tetramates, making use
of Dieckmann cyclization of oxazolidines derived from threo-arylserines, is reported; the …

Pathogenic bacteria, with their innate resistance to drugs, pose a constant threat to human
health and well-being and put a persistent strain on the health care system. Development of …

Isatin (1 H-indole-2, 3-Dione) and its derivatives are versatile compounds which acts as a
precursor for a large number of pharmacologically active compounds. Therefore isatins have …