Culturing of 'unculturable'human microbiota reveals novel taxa and extensive sporulation

HP Browne, SC Forster, BO Anonye, N Kumar… - Nature, 2016 - nature.com
Our intestinal microbiota harbours a diverse bacterial community required for our health,
sustenance and wellbeing,. Intestinal colonization begins at birth and climaxes with the …

A new genomic blueprint of the human gut microbiota

A Almeida, AL Mitchell, M Boland, SC Forster, GB Gloor… - Nature, 2019 - nature.com
The composition of the human gut microbiota is linked to health and disease, but knowledge
of individual microbial species is needed to decipher their biological roles. Despite …

Variation and transmission of the human gut microbiota across multiple familial generations

M Valles-Colomer, R Bacigalupe, S Vieira-Silva… - Nature …, 2022 - nature.com
Although the composition and functional potential of the human gut microbiota evolve over
the lifespan, kinship has been identified as a key covariate of microbial community …

Cultivation-based multiplex phenotyping of human gut microbiota allows targeted recovery of previously uncultured bacteria

EA Rettedal, H Gumpert, MOA Sommer - Nature communications, 2014 - nature.com
The human gut microbiota is linked to a variety of human health issues and implicated in
antibiotic resistance gene dissemination. Most of these associations rely on culture …

Environmental factors shaping the gut microbiome in a Dutch population

R Gacesa, A Kurilshikov, A Vich Vila, T Sinha… - Nature, 2022 - nature.com
The gut microbiome is associated with diverse diseases,–, but a universal signature of a
healthy or unhealthy microbiome has not been identified, and there is a need to understand …

A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research

M Poyet, M Groussin, SM Gibbons, J Avila-Pacheco… - Nature medicine, 2019 - nature.com
Our understanding of how the gut microbiome interacts with its human host has been
restrained by limited access to longitudinal datasets to examine stability and dynamics, and …

New insights from uncultivated genomes of the global human gut microbiome

S Nayfach, ZJ Shi, R Seshadri, KS Pollard… - Nature, 2019 - nature.com
The genome sequences of many species of the human gut microbiome remain unknown,
largely owing to challenges in cultivating microorganisms under laboratory conditions. Here …

Culture of previously uncultured members of the human gut microbiota by culturomics

JC Lagier, S Khelaifia, MT Alou, S Ndongo… - Nature …, 2016 - nature.com
Metagenomics revolutionized the understanding of the relations among the human
microbiome, health and diseases, but generated a countless number of sequences that …

Quantitative microbiome profiling links gut community variation to microbial load

D Vandeputte, G Kathagen, K D'hoe, S Vieira-Silva… - Nature, 2017 - nature.com
Current sequencing-based analyses of faecal microbiota quantify microbial taxa and
metabolic pathways as fractions of the sample sequence library generated by each …

Structure, function and diversity of the healthy human microbiome

nature, 2012 - nature.com
Studies of the human microbiome have revealed that even healthy individuals differ
remarkably in the microbes that occupy habitats such as the gut, skin and vagina. Much of …