Photoaffinity labeling (PAL) is a powerful technique in chemical biology and chemical
proteomics, and has been successfully demonstrated on a variety of non-covalent molecular …

The elucidation of substrate–protein interactions is an important component of the drug
development process. Due to the complexity of native cellular environments, elucidating …

Affinity‐based probes (AfBPs) provide a powerful tool for large‐scale chemoproteomic
studies of drug–target interactions. The development of high‐quality probes capable of …

Alkyl diazirines are frequently used in photoaffinity labeling to map small molecule–protein
interactions in target identification studies. However, the alkyl diazirines can preferentially …

Target identification is a high-priority, albeit challenging, aspect of drug discovery. Diazirine-
based photoaffinity probes (PAPs) can facilitate the process by covalently capturing transient …

Affinity‐based protein profiling (AfBPP) is a widely applied method for the target
identification of bioactive molecules. Probes containing photocrosslinkers, such as …

Diazirines are widely used in photoaffinity labeling (PAL) to trap noncovalent interactions
with biomolecules. However, design and interpretation of PAL experiments is challenging …

Target identification is often the rate‐determining step in deciphering the mechanism of
action of biologically active small molecules. Photo‐affinity labeling (PAL) represents a …

The use of photo-affinity reagents for the mapping of noncovalent small molecule–protein
interactions has become widespread. Recently, several 'fully-functionalized'(FF) chemical …

Photoaffinity labels are powerful tools for dissecting ligand–protein interactions, and they
have a broad utility in medicinal chemistry and drug discovery. Traditional photoaffinity …