[HTML][HTML] Tanshinone IIA Protects Against Cerebral Ischemia Reperfusion Injury by Regulating Microglial Activation and Polarization via NF-κB Pathway

Z Song, J Feng, Q Zhang, S Deng, D Yu… - Frontiers in …, 2021 - frontiersin.org
Tanshinone IIA, a fat-soluble diterpenoid isolated from Salvia miltiorrhiza Bunge, has been
shown to attenuate the cerebral ischemic injury. The aim of this study was to examine the …

Anti-inflammatory effect of tanshinone I in neuroprotection against cerebral ischemia–reperfusion injury in the gerbil hippocampus

JH Park, OK Park, JH Cho, BH Chen, IH Kim… - Neurochemical …, 2014 - Springer
Tanshinone I (TsI) is an important lipophilic diterpene extracted from Danshen (Radix Salvia
miltiorrhizae) and has been used in Asia for the treatment of cerebrovascular diseases such …

Neuroprotective capabilities of Tanshinone IIA against cerebral ischemia/reperfusion injury via anti-apoptotic pathway in rats

Y Chen, X Wu, S Yu, NJS Fauzee, J Wu, L Li… - Biological and …, 2012 - jstage.jst.go.jp
Danshen, derived from the dried root or rhizome of Salviae miltiorrhizae BGE., has
Tanshinone IIA (TSA) as one of its active ingredients. Recent reports have shown that TSA …

Tanshinone IIA protects hippocampal neuronal cells from reactive oxygen species through changes in autophagy and activation of phosphatidylinositol 3-kinase …

Y Zhu, Q Tang, G Wang, R Han - Current Neurovascular …, 2017 - ingentaconnect.com
Background: Tanshinone IIA is a key active ingredient of danshen, which is derived from the
dried root or rhizome of Salviae miltiorrhizae Bge. The tanshinone IIA has protective effects …

The protective effect of an extract of Salvia miltiorrhiza Bunge (Danshen) on cerebral ischemic injury in animal models: A systematic review and meta-analysis

X Xie, Y Xu, X Zhou, P Su, X Jiang, Z Jin - Journal of Ethnopharmacology, 2023 - Elsevier
Ethnopharmacological relevance Cerebral ischemia is a common disease that seriously
threatens the health of human beings. Tanshinone IIA (TSA) is a fat-soluble compound …

Tanshinone IIA attenuates the cerebral ischemic injury-induced increase in levels of GFAP and of caspases-3 and-8

L Zhou, SC Bondy, L Jian, P Wen, F Yang, H Luo, W Li… - Neuroscience, 2015 - Elsevier
Tanshinone IIA (TSA) is a lipid soluble agent derived from the root of Salvia miltiorrhiza
(Danshen). This plant is a traditional Chinese herb, which has been used widely in China …

Neuroprotection via maintenance or increase of antioxidants and neurotrophic factors in ischemic gerbil hippocampus treated with tanshinone Ⅰ

HP Joon, P Ok, B Yan, HA Ji, HK In… - Chinese Medical …, 2014 - mednexus.org
Background Danshen (Radix Salvia miltiorrhizae) has been used as a traditional medicine
in Asia for treatment of various microcirculatory disturbance related diseases. Tanshinones …

[HTML][HTML] Salvianolic acid A attenuates cerebral ischemia/reperfusion injury induced rat brain damage, inflammation and apoptosis by regulating miR-499a/DDK1

J Zhao, L Li, G Fang - American Journal of Translational Research, 2020 - ncbi.nlm.nih.gov
Background and objectives: Salvianolic acid A (SAA) is a main component derived from
Salvia miltiorrhiza and has been revealed to protect against cerebral ischemia/reperfusion …

[HTML][HTML] Genistein-3′-sodium sulfonate attenuates Neuroinflammation in stroke rats by Down-regulating microglial M1 polarization through α7nAChR-NF-κB …

C Liu, S Liu, L Xiong, L Zhang, X Li, X Cao… - … journal of biological …, 2021 - ncbi.nlm.nih.gov
Microglial M1 depolarization mediated prolonged inflammation contributing to brain injury in
ischemic stroke. Our previous study revealed that Genistein-3′-sodium sulfonate (GSS) …

Tanshinone IIA protected against lipopolysaccharide-induced brain injury through the protective effect of the blood–brain barrier and the suppression of oxidant stress …

X Wang, WM Wang, H Han, Y Zhang, JL Liu, JY Yu… - Food & Function, 2022 - pubs.rsc.org
Brain microvascular endothelial cells are essential components of the blood–brain barrier
(BBB) that acts as a selective physical barrier and plays protective roles in maintaining brain …