[PDF][PDF] Targeting ferroptosis to iron out cancer

B Hassannia, P Vandenabeele, TV Berghe - Cancer cell, 2019 - cell.com
One of the key challenges in cancer research is how to effectively kill cancer cells while
leaving the healthy cells intact. Cancer cells often have defects in cell death executioner …

Ferroptosis in cancer therapy: a novel approach to reversing drug resistance

C Zhang, X Liu, S Jin, Y Chen, R Guo - Molecular cancer, 2022 - Springer
Ferroptosis is an intracellular iron-dependent form of cell death that is distinct from
apoptosis, necrosis, and autophagy. Extensive studies suggest that ferroptosis plays a …

Ferroptosis in cancer: From molecular mechanisms to therapeutic strategies

Q Zhou, Y Meng, D Li, L Yao, J Le, Y Liu… - … and Targeted Therapy, 2024 - nature.com
Ferroptosis is a non-apoptotic form of regulated cell death characterized by the lethal
accumulation of iron-dependent membrane-localized lipid peroxides. It acts as an innate …

[HTML][HTML] Ferroptosis: the silver lining of cancer therapy

Z Tang, Z Huang, Y Huang, Y Chen… - Frontiers in Cell and …, 2021 - frontiersin.org
Regulatory cell death has been a hot research topic in cancer therapy and one of the
research directions to improve conventional clinical cancer treatment (eg, chemotherapy …

Targeting ferroptosis pathway to combat therapy resistance and metastasis of cancer

X Liu, Y Zhang, X Wu, F Xu, H Ma, M Wu… - Frontiers in …, 2022 - frontiersin.org
Ferroptosis is an iron-dependent regulated form of cell death caused by excessive lipid
peroxidation. This form of cell death differed from known forms of cell death in morphological …

Recent progress on targeting ferroptosis for cancer therapy

G Xu, H Wang, X Li, R Huang, L Luo - Biochemical Pharmacology, 2021 - Elsevier
Ferroptosis is a new mode of cell death different from cell necrosis, autophagy, apoptosis,
and pyroptosis, which depends on the accumulation of reactive oxygen species (ROS) …

Targeting ferroptosis as a vulnerability in cancer

G Lei, L Zhuang, B Gan - Nature Reviews Cancer, 2022 - nature.com
Ferroptosis is an iron-dependent form of regulated cell death that is triggered by the toxic
build-up of lipid peroxides on cellular membranes. In recent years, ferroptosis has garnered …

Induction and application of ferroptosis in cancer therapy

Q Nie, Y Hu, X Yu, X Li, X Fang - Cancer Cell International, 2022 - Springer
At present, more than one cell death pathways have been found, one of which is ferroptosis.
Ferroptosis was discovered in 2012 and described as an iron-dependent and lipid …

Ferroptosis as a potential target for cancer therapy

Z Chen, W Wang, SR Abdul Razak, T Han… - Cell death & …, 2023 - nature.com
Ferroptosis is a recently discovered essential type of cell death that is mainly characterized
by iron overload and lipid peroxidation. Emerging evidence suggests that ferroptosis is a …

Ferroptosis: a double-edged sword mediating immune tolerance of cancer

Q Dang, Z Sun, Y Wang, L Wang, Z Liu, X Han - Cell Death & Disease, 2022 - nature.com
The term ferroptosis was put forward in 2012 and has been researched exponentially over
the past few years. Ferroptosis is an unconventional pattern of iron-dependent programmed …