Aging causes a functional decline in tissues throughout the body that may be delayed by
caloric restriction (CR). However, the cellular profiles and signatures of aging, as well as …

Aging is accompanied by the functional decline of tissues. However, a systematic study of
epigenomic and transcriptomic changes across tissues during aging is missing. Here, we …

Background Caloric restriction (CR) counters deleterious effects of aging and, for most
mouse genotypes, increases mean and maximum lifespan. Previous analyses of microarray …

Humanity has been obsessed with extending life span and reversing the aging process
throughout recorded history and this quest most likely preceded the invention of the written …

Lifespan varies within and across species, but the general principles of its control remain
unclear. Here, we conducted multi-tissue RNA-seq analyses across 41 mammalian species …

Calorie restriction (CR) is the most robust non-genetic intervention to delay aging. However,
there are a number of emerging experimental variables that alter CR responses. We …

Aging is associated with complex molecular and cellular processes that are poorly
understood. Here we leveraged the Tabula Muris Senis single-cell RNA-seq data set to …

Caloric restriction, a reduction in calorie intake without malnutrition, retards age-related
degeneration and extends lifespan in several organisms. CR induces multiple changes, yet …

Ageing is characterized by a progressive loss of physiological integrity, leading to impaired
function and increased vulnerability to death. Despite rapid advances over recent years …

Aging is characterized by progressive loss of physiological and cellular functions, but the
molecular basis of this decline remains unclear. We explored how aging affects …