[HTML][HTML] Current status and future perspectives in targeted therapy of NPM1-mutated AML
Abstract Nucleophosmin 1 (NPM1) is a nucleus-cytoplasmic shuttling protein which is
predominantly located in the nucleolus and exerts multiple functions, including regulation of …
predominantly located in the nucleolus and exerts multiple functions, including regulation of …
NPM1-mutated acute myeloid leukemia: from bench to bedside
The nucleophosmin (NPM1) gene encodes for a multifunctional protein with prominent
nucleolar localization that shuttles between nucleus and cytoplasm. NPM1 mutations …
nucleolar localization that shuttles between nucleus and cytoplasm. NPM1 mutations …
Acute myeloid leukemia with mutated nucleophosmin (NPM1): any hope for a targeted therapy?
B Falini, I Gionfriddo, F Cecchetti, S Ballanti… - Blood reviews, 2011 - Elsevier
Acute myeloid leukemia (AML) carrying nucleophosmin (NPM1) mutations displays distinct
molecular and clinical–pathological features that led to its inclusion as provisional entity in …
molecular and clinical–pathological features that led to its inclusion as provisional entity in …
Nucleophosmin (NPM1) mutations in adult and childhood acute myeloid leukaemia: towards definition of a new leukaemia entity
R Rau, P Brown - Hematological oncology, 2009 - Wiley Online Library
Nucleophosmin (NPM) is a ubiquitously expressed chaperone protein that shuttles rapidly
between the nucleus and cytoplasm, but predominantly resides in the nucleolus. It plays key …
between the nucleus and cytoplasm, but predominantly resides in the nucleolus. It plays key …
Nucleophosmin1 (NPM1) abnormality in hematologic malignancies, and therapeutic targeting of mutant NPM1 in acute myeloid leukemia
Y Chen, J Hu - Therapeutic advances in hematology, 2020 - journals.sagepub.com
Nucleophosmin (NPM1) is an abundant nucleolar protein that is implicated in a variety of
biological processes and in the pathogenesis of several human malignancies. For …
biological processes and in the pathogenesis of several human malignancies. For …
Nucleophosmin mutations in acute myeloid leukemia: a tale of protein unfolding and mislocalization
L Federici, B Falini - Protein science, 2013 - Wiley Online Library
Nucleophosmin (NPM1) is an abundant, ubiquitously expressed protein mainly localized at
nucleoli but continuously shuttling between nucleus and cytoplasm. NPM1 plays a role in …
nucleoli but continuously shuttling between nucleus and cytoplasm. NPM1 plays a role in …
[HTML][HTML] Nucleophosmin 1 mutations in acute myeloid leukemia
Nucleophosmin (NPM1) is a ubiquitously expressed nucleolar protein involved in ribosome
biogenesis, the maintenance of genomic integrity and the regulation of the ARF-p53 tumor …
biogenesis, the maintenance of genomic integrity and the regulation of the ARF-p53 tumor …
When the good go bad: mutant NPM1 in acute myeloid leukemia
P Kunchala, S Kuravi, R Jensen, J McGuirk, R Balusu - Blood reviews, 2018 - Elsevier
Abstract Nucleophosmin 1 (NPM1) is a nucleolar phosphoprotein that performs diverse
biological functions including molecular chaperoning, ribosome biogenesis, DNA repair …
biological functions including molecular chaperoning, ribosome biogenesis, DNA repair …
[HTML][HTML] Significance of NPM1 gene mutations in AML
A Hindley, MA Catherwood, MF McMullin… - International journal of …, 2021 - mdpi.com
The aim of this literature review is to examine the significance of the nucleophosmin 1
(NPM1) gene in acute myeloid leukaemia (AML). This will include analysis of the structure …
(NPM1) gene in acute myeloid leukaemia (AML). This will include analysis of the structure …
Acute myeloid leukemia carrying cytoplasmic/mutated nucleophosmin (NPMc+ AML): biologic and clinical features
B Falini, I Nicoletti, MF Martelli, C Mecucci - Blood, 2007 - ashpublications.org
The nucleophosmin (NPM1) gene encodes for a multifunctional nucleocytoplasmic shuttling
protein that is localized mainly in the nucleolus. NPM1 mutations occur in 50% to 60% of …
protein that is localized mainly in the nucleolus. NPM1 mutations occur in 50% to 60% of …