Investigation of the protective mechanism of leonurine against acute myocardial ischemia by an integrated metabolomics and network pharmacology strategy

W Rong, J Li, L Wang, S Luo, T Liang… - Frontiers in …, 2022 - frontiersin.org
Background Leonurus japonicus Houtt has an obvious efficacy on cardiovascular diseases.
As the most representative component in the herb, leonurine has attracted increasing …

Cardioprotective Mechanism of Leonurine against Myocardial Ischemia through a Liver–Cardiac Crosstalk Metabolomics Study

W Rong, J Li, D Pan, Q Zhou, Y Zhang, Q Lu, L Wang… - Biomolecules, 2022 - mdpi.com
Leonurine has been shown to have excellent anti-myocardial ischemia effects. Our previous
studies suggested that cardiac protection by leonurine during myocardial ischemia …

Leonurine improves ischemia-induced myocardial injury through antioxidative activity

XH Liu, LL Pan, PF Chen, YZ Zhu - Phytomedicine, 2010 - Elsevier
The present study was designed to investigate the protective effects of 4-guanidino-n-butyl
syringate (leonurine), a compound in Herba Leonuri (HL) on ischemic rat heart to determine …

Leonurine protects cardiac function following acute myocardial infarction through anti‑apoptosis by the PI3K/AKT/GSK3β signaling pathway Corrigendum in/10.3892 …

L Xu, X Jiang, F Wei, H Zhu - Molecular medicine …, 2018 - spandidos-publications.com
Leonurine is a compound derived from Herba leonuri, which has been reported to protect
cardiac tissue against ischemic injury via antioxidant and anti‑apoptosis effects. The present …

Integrated network pharmacology and metabonomics to reveal the myocardial protection effect of Huang-Lian-Jie-Du-Tang on myocardial ischemia

L Li, W Dai, W Li, Y Zhang, Y Wu, C Guan… - Frontiers in …, 2021 - frontiersin.org
Myocardial ischemia (MI) is one of the most common cardiovascular diseases with high
incidence and mortality. Huang-Lian-Jie-Du-Tang (HLJDT) is a classic traditional Chinese …

Beneficial effects of oridonin on myocardial ischemia/reperfusion injury: insight gained by metabolomic approaches

J Zhang, Y Zhou, Y Sun, H Yan, W Han, X Wang… - European Journal of …, 2019 - Elsevier
Oridonin is a diterpenoid isolated from Rabdosia rubescens (Hemsl.) Hara, a well-known
herbal tea in China with many health benefits. To provide a better understanding of the …

Integrated metabolomics and network toxicology to reveal molecular mechanism of celastrol induced cardiotoxicity

C Liu, C Zhang, W Wang, F Yuan, T He, Y Chen… - Toxicology and Applied …, 2019 - Elsevier
Celastrol (CS), an active triterpene derived from traditional Chinese medicine Tripterygium
wilfordii Hook. f, has been used to treat chronic inflammation, arthritis and other diseases …

Comparative metabonomics of Wenxin Keli and Verapamil reveals differential roles of gluconeogenesis and fatty acid β-oxidation in myocardial injury protection

M Jiang, Q Wang, J Chen, Y Wang, G Fan, Y Zhu - Scientific reports, 2017 - nature.com
Metabonomics/metabolomics is a rapid technology for comprehensive profiling of small
molecule metabolites in cells, tissues, or whole organisms, the application of which has led …

Targeted arginine metabolomics combined with metagenomics revealed the potential mechanism of Pueraria lobata extract in treating myocardial infarction

B Yi, Y Zhao, H Yan, Z Li, P Zhang, Z Fang… - … of Chromatography A, 2024 - Elsevier
The extraction methods for traditional Chinese medicine (TCM) may have varying
therapeutic effects on diseases. Currently, Pueraria lobata (PL) is mostly extracted with …

[HTML][HTML] Leonurine affected homocysteine‐methionine metabolism based on metabolomics and gut microbiota studies of clinical trial samples

J Liao, R Suguro, X Zhao, Y Yu, Y Cui… - Clinical and …, 2021 - ncbi.nlm.nih.gov
Dear Editor, Cardiovascular disease (CVD) remains the leading cause of mortality globally,
taking several millions of lives every year. Various risk factors for CVD have been identified …