Investigation of the protective mechanism of leonurine against acute myocardial ischemia by an integrated metabolomics and network pharmacology strategy
W Rong, J Li, L Wang, S Luo, T Liang… - Frontiers in …, 2022 - frontiersin.org
Background Leonurus japonicus Houtt has an obvious efficacy on cardiovascular diseases.
As the most representative component in the herb, leonurine has attracted increasing …
As the most representative component in the herb, leonurine has attracted increasing …
Cardioprotective Mechanism of Leonurine against Myocardial Ischemia through a Liver–Cardiac Crosstalk Metabolomics Study
W Rong, J Li, D Pan, Q Zhou, Y Zhang, Q Lu, L Wang… - Biomolecules, 2022 - mdpi.com
Leonurine has been shown to have excellent anti-myocardial ischemia effects. Our previous
studies suggested that cardiac protection by leonurine during myocardial ischemia …
studies suggested that cardiac protection by leonurine during myocardial ischemia …
Leonurine improves ischemia-induced myocardial injury through antioxidative activity
The present study was designed to investigate the protective effects of 4-guanidino-n-butyl
syringate (leonurine), a compound in Herba Leonuri (HL) on ischemic rat heart to determine …
syringate (leonurine), a compound in Herba Leonuri (HL) on ischemic rat heart to determine …
Leonurine protects cardiac function following acute myocardial infarction through anti‑apoptosis by the PI3K/AKT/GSK3β signaling pathway Corrigendum in/10.3892 …
L Xu, X Jiang, F Wei, H Zhu - Molecular medicine …, 2018 - spandidos-publications.com
Leonurine is a compound derived from Herba leonuri, which has been reported to protect
cardiac tissue against ischemic injury via antioxidant and anti‑apoptosis effects. The present …
cardiac tissue against ischemic injury via antioxidant and anti‑apoptosis effects. The present …
Integrated network pharmacology and metabonomics to reveal the myocardial protection effect of Huang-Lian-Jie-Du-Tang on myocardial ischemia
L Li, W Dai, W Li, Y Zhang, Y Wu, C Guan… - Frontiers in …, 2021 - frontiersin.org
Myocardial ischemia (MI) is one of the most common cardiovascular diseases with high
incidence and mortality. Huang-Lian-Jie-Du-Tang (HLJDT) is a classic traditional Chinese …
incidence and mortality. Huang-Lian-Jie-Du-Tang (HLJDT) is a classic traditional Chinese …
Beneficial effects of oridonin on myocardial ischemia/reperfusion injury: insight gained by metabolomic approaches
J Zhang, Y Zhou, Y Sun, H Yan, W Han, X Wang… - European Journal of …, 2019 - Elsevier
Oridonin is a diterpenoid isolated from Rabdosia rubescens (Hemsl.) Hara, a well-known
herbal tea in China with many health benefits. To provide a better understanding of the …
herbal tea in China with many health benefits. To provide a better understanding of the …
Integrated metabolomics and network toxicology to reveal molecular mechanism of celastrol induced cardiotoxicity
C Liu, C Zhang, W Wang, F Yuan, T He, Y Chen… - Toxicology and Applied …, 2019 - Elsevier
Celastrol (CS), an active triterpene derived from traditional Chinese medicine Tripterygium
wilfordii Hook. f, has been used to treat chronic inflammation, arthritis and other diseases …
wilfordii Hook. f, has been used to treat chronic inflammation, arthritis and other diseases …
Comparative metabonomics of Wenxin Keli and Verapamil reveals differential roles of gluconeogenesis and fatty acid β-oxidation in myocardial injury protection
Metabonomics/metabolomics is a rapid technology for comprehensive profiling of small
molecule metabolites in cells, tissues, or whole organisms, the application of which has led …
molecule metabolites in cells, tissues, or whole organisms, the application of which has led …
Targeted arginine metabolomics combined with metagenomics revealed the potential mechanism of Pueraria lobata extract in treating myocardial infarction
B Yi, Y Zhao, H Yan, Z Li, P Zhang, Z Fang… - … of Chromatography A, 2024 - Elsevier
The extraction methods for traditional Chinese medicine (TCM) may have varying
therapeutic effects on diseases. Currently, Pueraria lobata (PL) is mostly extracted with …
therapeutic effects on diseases. Currently, Pueraria lobata (PL) is mostly extracted with …
[HTML][HTML] Leonurine affected homocysteine‐methionine metabolism based on metabolomics and gut microbiota studies of clinical trial samples
J Liao, R Suguro, X Zhao, Y Yu, Y Cui… - Clinical and …, 2021 - ncbi.nlm.nih.gov
Dear Editor, Cardiovascular disease (CVD) remains the leading cause of mortality globally,
taking several millions of lives every year. Various risk factors for CVD have been identified …
taking several millions of lives every year. Various risk factors for CVD have been identified …
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