The emergence of diuretic drugs and angiotensin converting enzyme (ACE) inhibitors ranks
amongst the major therapeutic advances of modern medicine. The discovery of these drug …

The central role of the renin-angiotensin-aldosterone system in the regulation of fluid
balance and haemodynamics was not fully appreciated until the discovery and clinical …

The renin-angiotensin system has a wide range of physiological actions, and thus
interference with the system has attractive therapeutic potential. The orally active …

ACE inhibitors effectively reduce systemic vascular resistance in patients with hypertension,
heart failure or chronic renal disease. This antihypertensive efficacy probably accounts for …

Overt proteinuria is often accompanied by hypercholesterolemia and is associated with
increased lipoprotein (a) levels. These lipid abnormalities are probably involved in the high …

Renal diseases as glomerulonephritis, diabetic nephropathy, interstitial nephritis (eg
analgetic nephropathy) or systemic disease with renal involvement are responsible for renal …

The angiotensin converting enzyme (ACE)-inhibiting agents have emerged with the diuretic
agents, beta-adrenergic receptor-blocking agents, and calcium antagonists as therapeutic …

Angiotensin converting enzyme inhibition (ACEI) has proved to be an effective
pharmacological tool in unraveling the various physiological functions of the renin …

Diuretics increase the rate of urine flow and sodium excretion and are used to adjust the
volume and/or composition of body fluids in a variety of clinical situations, including …

Diuretics have been used successfully as antihypertensive drugs for over 30 years. In 1957,
chlorothiazide was introduced into clinical trials to treat hypertensive patients (H ollander …