Drug addiction is associated with long-lasting neuronal adaptations including alterations in
dopamine and glutamate receptors in the brain reward system. Treatment strategies for …

The ventral striatum/nucleus accumbens has been implicated in the craving for drugs and
alcohol which is a major reason for relapse of addicted people. Craving might be induced by …

In order to explore a novel method for the treatment of drug abuse, we evaluated the effect of
chronic deep brain stimulation (DBS) of the rat nucleus accumbens (NAc) on morphine …

Cocaine stimuli often trigger relapse of drug‐taking, even following periods of prolonged
abstinence. Here, electrophysiological recordings were made in rats (n= 29) to determine …

Drug addiction is a chronic, relapsing brain disorder characterized by compulsive drug use.
Contemporary addiction theories state that loss of control over drug use is mediated by a …

Vulnerability to drug related cues is one of the leading causes for continued use and relapse
among substance dependent individuals. Using drugs in the face of cues may be associated …

Stimuli previously associated with drug taking can become triggers that can elicit craving
and lead to relapse of drug-seeking behavior. Here, we examined the influence of deep …

High rates of relapse after prolonged abstinence are often triggered by exposure to drug-
associated cues that induce drug craving. Incubation of drug craving is a phenomenon that …

BACKGROUND: Although cocaine dependence (CD) involves abnormalities in drug-related,
reward-based decision making, it is not well understood whether these abnormalities …

Deep brain stimulation (DBS) of the nucleus accumbens (NAc) is a potential remedial
therapy for drug craving and relapse, but the mechanism is poorly understood. We …