Introduction: The first two alpha2delta ligands–gabapentin (GBP) and pregabalin (PGB)–
were initially synthesized as antiepileptics; however, they were later also found to be useful …

Pregabalin is a new synthetic molecule and a structural derivative of the inhibitory
neurotransmitter γ-aminobutyric acid. It is an α 2-δ (α 2-δ) ligand that has analgesic …

Mirogabalin besylate (hereafter mirogabalin)[Tarlige®] is an orally administered
gabapentinoid developed by Daiichi Sankyo for the treatment of peripheral neuropathic pain …

Pregabalin is an antagonist of voltage gated Ca2+ channels and specifically binds to alpha-
2-delta subunit to produce antiepileptic and analgesic actions. It successfully alleviates the …

Pregabalin is an anticonvulsant drug that binds to the α2δ (alpha2delta) subunit of the
voltage-dependent calcium channel in central nervous system (CNS). Pregabalin decreases …

Used mainly for the management of neuropathic pain, pregabalin is a gabapentinoid or
anticonvulsant that was initially developed as an antiepileptic agent. After more than a …

BACKGROUND:: The US Food and Drug Administration (FDA) approved pregabalin in
December 2004 for the treatment of neuropathic pain associated with diabetic peripheral …

Pregabalin, a compound with a novel mechanism of action (MOA), has demonstrated
efficacy as an adjunctive treatment for epilepsy and in several neuropathic pain models …

Abstract▴ Pregabalin, the pharmacologically active S-enantiomerof 3-aminomethyl-5-methyl-
hexanoic acid, has a similar pharmacological profile to that of its developmental …

Pregabalin is a specific ligand of the alpha 2-delta (α 2-δ) auxiliary subunit of voltage-gated
calcium channels. A growing body of evidence from studies of anxiety and pain indicate that …