Chromatin modifier developmental pluripotency associated factor 4 (DPPA4) is a candidate gene for alcohol-induced developmental disorders

P Auvinen, J Vehviläinen, H Marjonen, V Modhukur… - BMC medicine, 2022 - Springer
Background Prenatal alcohol exposure (PAE) affects embryonic development, causing a
variable fetal alcohol spectrum disorder (FASD) phenotype with neuronal disorders and birth …

Alcohol exposure alters DNA methylation profiles in mouse embryos at early neurulation

Y Liu, Y Balaraman, G Wang, KP Nephew, FC Zhou - Epigenetics, 2009 - Taylor & Francis
Alcohol exposure during development can cause variable neurofacial deficit and growth
retardation known as fetal alcohol spectrum disorders (FASD). The mechanism underlying …

DNA methylation signature of human fetal alcohol spectrum disorder

E Portales-Casamar, AA Lussier, MJ Jones… - Epigenetics & …, 2016 - Springer
Background Prenatal alcohol exposure is the leading preventable cause of behavioral and
cognitive deficits, which may affect between 2 and 5% of children in North America. While …

Associative DNA methylation changes in children with prenatal alcohol exposure

BI Laufer, J Kapalanga, CA Castellani, EJ Diehl… - …, 2015 - Taylor & Francis
Aim: Prenatal alcohol exposure (PAE) can cause fetal alcohol spectrum disorders (FASD).
Previously, we assessed PAE in brain tissue from mouse models, however whether these …

Prenatal alcohol exposure: profiling developmental DNA methylation patterns in central and peripheral tissues

AA Lussier, TS Bodnar, M Mingay, AM Morin… - Frontiers in …, 2018 - frontiersin.org
Background: Prenatal alcohol exposure (PAE) can alter the development of neurobiological
systems, leading to lasting neuroendocrine, neuroimmune, and neurobehavioral deficits …

Expression quantitative trait methylation analysis identifies whole blood molecular footprint in fetal alcohol spectrum disorder (FASD)

IM Krzyzewska, P Lauffer, AN Mul… - International journal of …, 2023 - mdpi.com
Fetal alcohol spectrum disorder (FASD) encompasses neurodevelopmental disabilities and
physical birth defects associated with prenatal alcohol exposure. Previously, we attempted …

DNA methylation as a predictor of fetal alcohol spectrum disorder

AA Lussier, AM Morin, JL MacIsaac, J Salmon… - Clinical …, 2018 - Springer
Background Fetal alcohol spectrum disorder (FASD) is a developmental disorder that
manifests through a range of cognitive, adaptive, physiological, and neurobiological deficits …

Meta‐Analysis of Gene Expression Patterns in Animal Models of Prenatal Alcohol Exposure Suggests Role for Protein Synthesis Inhibition and Chromatin Remodeling

S Rogic, A Wong, P Pavlidis - Alcoholism: Clinical and …, 2016 - Wiley Online Library
Background Prenatal alcohol exposure (PAE) can result in an array of morphological,
behavioral, and neurobiological deficits that can range in their severity. Despite extensive …

Cell type-specific changes in Wnt signaling and neuronal differentiation in the developing mouse cortex after prenatal alcohol exposure during neurogenesis

D Sambo, C Gohel, Q Yuan, G Sukumar… - Frontiers in Cell and …, 2022 - frontiersin.org
Fetal Alcohol Spectrum Disorder (FASD) encompasses an array of effects of prenatal
alcohol exposure (PAE), including physical abnormalities and cognitive and behavioral …

Pre-implantation alcohol exposure and developmental programming of FASD: an epigenetic perspective

LM Legault, V Bertrand-Lehouillier… - Biochemistry and cell …, 2018 - cdnsciencepub.com
Exposure to alcohol during in-utero development can permanently change the
developmental programming of physiological responses, thereby increasing the risk of …