Background Several theories propose alternative explanations for drug addiction. Objectives
We propose a general theory of transition to addiction that synthesizes knowledge …

Piazza and Deroche-Gamonet have significantly contributed to the field of addiction and
published several pioneering articles that have had a major influence on the field. The latest …

Drug addiction is a complex neuropsychiatric disorder that affects a subset of the individuals
who take drugs. It is characterized by maladaptive drug-seeking habits that are maintained …

Drug addiction is responsible for millions of deaths per year around the world. Still, its
management as a chronic disease is shadowed by misconceptions from the general public …

Drug addiction manifests as a compulsive drive to take a drug despite serious adverse
consequences. This aberrant behaviour has traditionally been viewed as bad'choices' that …

Using addictive drugs can evolve from controlled social use into the compulsive relapsing
disorder that characterizes addiction. This transition to addiction results from genetic …

Drug addiction is a progressive, relapsing disease comprised of interlocking stages of
disordered motivation. Numerous animal models describing various stages of the addiction …

Drug addiction presents as a chronic relapsing disorder characterized by persistent drug‐
seeking and drug‐taking behaviours. Given the significant detrimental effects of this disease …

How much, how often and how fast a drug reaches the brain determine the behavioural and
neuroplastic changes associated with the addiction process. Despite the critical nature of …

Adaptation of the nervous system to different chemical and physiologic conditions is
important for the homeostasis of brain processes and for learning and remembering …