The pathophysiology of type 2 diabetes mellitus (DM) is varied and complex. However, the
association of DM with obesity and inactivity indicates an important, and potentially …

Insulin resistance (IR) is fundamental to the development of type 2 diabetes (T2D) and is
present in most prediabetic (preDM) individuals. Insulin resistance has both heritable and …

Human mitochondria can be studied either in biopsies or by measuring flux through ATP
synthase and phosphocreatine recovery using magnetic resonance spectroscopy …

The specific cellular underpinnings or mechanisms of insulin resistance (IR) are not clear.
Here I present evidence to support a causal association between mitochondrial energetics …

Insulin resistance precedes and predicts the onset of type 2 diabetes (T2D) in susceptible
humans, underscoring its important role in the complex pathogenesis of this disease. Insulin …

Significance: Insulin resistance and its related diseases, obesity and type 2 diabetes mellitus
(T2DM), have been linked to changes in aerobic metabolism, pointing to a possible role of …

Mitochondrial dysfunction has been implicated in the development of insulin resistance (IR);
however, a large variety of association and intervention studies as well as genetic …

Diabetes profoundly alters fuel metabolism; both insulin deficiency and insulin resistance
are characterized by inefficient mitochondrial coupling and excessive production of reactive …

Mitochondrial metabolism is a major determinant of insulin secretion from pancreatic β-cells.
Type 2 diabetes evolves when β-cells fail to release appropriate amounts of insulin in …

Type 2 diabetes mellitus (T2DM) has been related to alterations of oxidative metabolism in
insulin-responsive tissues. Overt T2DM can present with acquired or inherited reductions of …