The role of mitochondria in the pathogenesis of type 2 diabetes
The pathophysiology of type 2 diabetes mellitus (DM) is varied and complex. However, the
association of DM with obesity and inactivity indicates an important, and potentially …
association of DM with obesity and inactivity indicates an important, and potentially …
Mitochondrial dysfunction, insulin resistance, and potential genetic implications: potential role of alterations in mitochondrial function in the pathogenesis of insulin …
P Sangwung, KF Petersen, GI Shulman… - …, 2020 - academic.oup.com
Insulin resistance (IR) is fundamental to the development of type 2 diabetes (T2D) and is
present in most prediabetic (preDM) individuals. Insulin resistance has both heritable and …
present in most prediabetic (preDM) individuals. Insulin resistance has both heritable and …
Mitochondrial fitness and insulin sensitivity in humans
J Szendroedi, M Roden - Diabetologia, 2008 - Springer
Human mitochondria can be studied either in biopsies or by measuring flux through ATP
synthase and phosphocreatine recovery using magnetic resonance spectroscopy …
synthase and phosphocreatine recovery using magnetic resonance spectroscopy …
Mitochondrial deficiency is associated with insulin resistance
BH Goodpaster - Diabetes, 2013 - Am Diabetes Assoc
The specific cellular underpinnings or mechanisms of insulin resistance (IR) are not clear.
Here I present evidence to support a causal association between mitochondrial energetics …
Here I present evidence to support a causal association between mitochondrial energetics …
Insulin resistance and mitochondrial dysfunction
A Gonzalez-Franquesa, ME Patti - Mitochondrial Dynamics in …, 2017 - Springer
Insulin resistance precedes and predicts the onset of type 2 diabetes (T2D) in susceptible
humans, underscoring its important role in the complex pathogenesis of this disease. Insulin …
humans, underscoring its important role in the complex pathogenesis of this disease. Insulin …
Mitochondrial plasticity in obesity and diabetes mellitus
T Jelenik, M Roden - Antioxidants & redox signaling, 2013 - liebertpub.com
Significance: Insulin resistance and its related diseases, obesity and type 2 diabetes mellitus
(T2DM), have been linked to changes in aerobic metabolism, pointing to a possible role of …
(T2DM), have been linked to changes in aerobic metabolism, pointing to a possible role of …
[HTML][HTML] Mitochondrial dysfunction and insulin resistance: an update
MK Montgomery, N Turner - Endocrine connections, 2015 - ec.bioscientifica.com
Mitochondrial dysfunction has been implicated in the development of insulin resistance (IR);
however, a large variety of association and intervention studies as well as genetic …
however, a large variety of association and intervention studies as well as genetic …
Altered mitochondrial function in insulin-deficient and insulin-resistant states
GN Ruegsegger, AL Creo, TM Cortes… - The Journal of …, 2018 - Am Soc Clin Investig
Diabetes profoundly alters fuel metabolism; both insulin deficiency and insulin resistance
are characterized by inefficient mitochondrial coupling and excessive production of reactive …
are characterized by inefficient mitochondrial coupling and excessive production of reactive …
The pathogenetic role of β-cell mitochondria in type 2 diabetes
Mitochondrial metabolism is a major determinant of insulin secretion from pancreatic β-cells.
Type 2 diabetes evolves when β-cells fail to release appropriate amounts of insulin in …
Type 2 diabetes evolves when β-cells fail to release appropriate amounts of insulin in …
The role of mitochondria in insulin resistance and type 2 diabetes mellitus
J Szendroedi, E Phielix, M Roden - Nature Reviews Endocrinology, 2012 - nature.com
Type 2 diabetes mellitus (T2DM) has been related to alterations of oxidative metabolism in
insulin-responsive tissues. Overt T2DM can present with acquired or inherited reductions of …
insulin-responsive tissues. Overt T2DM can present with acquired or inherited reductions of …