Drug discovery and development is a high-risk, expensive endeavor and it commonly takes
about 10− 15 years to obtain marketing approval from project inception. 1 Research efforts …

Imaging mass spectrometry (IMS) encompasses a variety of techniques that enable the
chemical imaging of analytes, which range in size from atoms and small molecules to intact …

During the past decade, mass spectrometry imaging (MSI) has become a robust and
versatile methodology to support modern pharmaceutical research and development. The …

Since its introduction mass spectrometry imaging (MSI) has proven to be a powerful tool for
the localization of molecules in biological tissues. In drug discovery and development …

Understanding the biodistribution, metabolism and accumulation of drugs in the body is a
fundamental of pharmaceutical research and development. Mass Spectrometry imaging …

The ability of mass spectrometry imaging (MSI) to localize panels of biomolecules in tissues,
without prior knowledge of their presence and in a label-free manner, has led to a rapid and …

In pharmaceutical research, understanding the biodistribution, accumulation and
metabolism of drugs in tissue plays a key role during drug discovery and development. In …

Mass spectrometric imaging (MSI) is a powerful analytical technique that provides two-and
three-dimensional spatial maps of multiple compounds in a single experiment. This …

Mass spectrometric imaging (MSI) has rapidly increased its presence in the pharmaceutical
sciences. While quantitative whole-body autoradiography and microautoradiography are the …

Mass spectrometry imaging (MSI) provides insight into the molecular distribution of a broad
range of compounds and, therefore, is frequently applied in the pharmaceutical industry …