Glycans modify lipids and proteins to mediate inter-and intramolecular interactions across all
domains of life. RNA is not thought to be a major target of glycosylation. Here, we challenge …

Cellular carbohydrates or glycans are critical mediators of biological function. Their
remarkably diverse structures and varied activities present exciting opportunities for …

Simple and complex carbohydrates (glycans) have long been known to play major
metabolic, structural and physical roles in biological systems. Targeted microbial binding to …

Cell surface glycans form a critical interface with the biological milieu, informing diverse
processes from the inflammatory cascade to cellular migration. Assembly of discrete …

Little is known about the biological roles of glycosylated RNAs (glycoRNAs), a recently
discovered class of glycosylated molecules, because of a lack of visualization methods. We …

RNAs localizing to the outer cell surface have been recently identified in mammalian cells,
including RNAs with glycan modifications known as glycoRNAs. However, the functional …

Noncoding RNA regulators have been implicated in almost all imaginable cellular
processes. Here we review how regulatory small RNAs such as Spot42, SgrS, GlmY, and …

This chapter provides an overview of the biological functions of glycans in three broad
categories: structural roles in, on, and outside cells; energy metabolism, including nutrient …

Many glycan-binding proteins in animals and pathogens recognize sialic acid or its modified
forms, but their molecular recognition is poorly understood. Here we describe studies on …

Insects, yeasts and plants generate widely different N-glycans, the structures of which differ
significantly from those produced by mammals. The processing of the initial …