This Opinion article discusses emerging evidence of direct contributions of nicotine to
cancer onset and growth. The list of cancers reportedly connected to nicotine is expanding …

Tobacco use is considered the single most important man-made cause of cancer that can be
avoided. The evidence that nicotine is involved in cancer development is reviewed and …

The genotoxic effects of tobacco carcinogens have long been recognized, the contribution of
tobacco components to cancerogenesis by cell surface receptor signaling is relatively …

Tobacco smoke contains multiple classes of established carcinogens including benzo (a)
pyrenes, polycyclic aromatic hydrocarbons, and tobacco-specific nitrosamines. Most of these …

Cigarette smoking is highly correlated with the onset of a variety of human cancers, and
continued smoking is known to abrogate the beneficial effects of cancer therapy. While …

Forty-eight million Americans smoke because of addiction to nicotine, and prevention of
smoking initiation and new methods for aiding in smoking cessation are some of the most …

Despite the known adverse health effects associated with tobacco use, over 45 million
adults in the United States smoke. Cigarette smoking is the major etiologic factor associated …

Nowadays, tobacco smoking is the cause of~ 5–6 million deaths per year, counting 31% and
6% of all cancer deaths (affecting 18 different organs) in middle-aged men and women …

A substantial number of the world's population continues to smoke tobacco, even in the
setting of a cancer diagnosis. Studies have shown that patients with cancer who have a …

Nicotinic acetylcholine receptors (nAChRs) are ion channels that are expressed in the cell
membrane of all mammalian cells, including cancer cells. Recent findings suggest that …