Acute myeloid leukemia is characterized by arrested differentiation, and agents that
overcome this block are therapeutically useful, as shown by the efficacy of all-trans retinoic …

Acute myeloid leukemia (AML) is characterized by the accumulation of malignant blasts with
impaired differentiation programs caused by recurrent mutations, such as the isocitrate …

Acute myeloid leukemia (AML) is characterized by impaired hematopoiesis and bone
marrow failure caused by clonal expansion of undifferentiated myeloid precursors. The …

With rapid advances in sequencing technologies, tremendous progress has been made in
understanding the molecular pathogenesis of acute myeloid leukaemia (AML), thus …

Abstract Purpose of Review Over the past decade, the pathogenic role of mutations in
isocitrate dehydrogenases (IDH) 1 and 2, affecting approximately 20% of patients with AML …

Simple Summary Acute myeloid leukemia (AML) is one of the most common types of
leukemia in adults, with an average first diagnosis at age 68, and has historically carried …

The last decade has witnessed rapid advances in our understanding of molecular
leukemogenesis providing valuable insights from which to explore new therapeutic …

Blocked cellular differentiation is a central pathologic feature of the myeloid malignancies,
myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Treatment regimens …

Acute myeloid leukemia (AML) is characterized by impaired differentiation and indefinite
proliferation of abnormal myeloid progenitors. Although differentiating agents were deemed …

For decades, researchers have looked into the pathophysiology of acute myeloid leukemia
(AML). With the advances in molecular techniques, the two-hit hypothesis was replaced by a …