Recently, we described a two-pool model for 3, 5, 3'-triiodothyronine uptake and metabolism
in the isolated perfused rat liver. Here, we applied this model to investigate transmembrane …

The effects of 48-h fasting on transport of T3 and subsequent metabolism in the isolated
perfused rat liver were investigated. Tracer T3 disappearance curves from the recirculating …

To investigate the mechanism by which thyroxine (T4) in plasma enters hepatic cells, we
measured the rate constants for uptake of free T4 by the perfused rat liver and for …

To investigate the mechanism by which T3 in plasma enters hepatic cells, we measured rate
constants for the uptake of unbound (free) T3 by the perfused rat liver, for the hepatic uptake …

The transport and subsequent metabolism of triiodothyronine (T 3) were studied in isolated
perfused livers of euthyroid, hypothyroid, and hyperthyroid rats, both fed and 48-hour-fasted …

Nonthyroidal illness (NTI) and fasting in man are characterized by a low serum
concentration of T3 and an increased serum concentration of rT3. Since the serum level of …

The transport of [125I] thyroxine (T4) and [125I] triiodothyronine (T3) into liver was
investigated with a tissue sampling-portal vein injection technique in the anesthetized rat …

The hepatic nuclear receptor for T3 is known to be approximately 50% saturated in vivo.
Since the receptor dissociation constant (Kd) is 1 nM, and since 50% receptor occupancy …

OBJECTIVE Inhibitors of cellular T4 transport leading to diminished plasma T3 production
have been identified as 3‐carboxy‐4‐methyl‐5‐propyl‐2‐furanpropanoic acid (CMPF) and …

Thyroid hormone uptake into cultured human hepatocytes was studied using measurement
of cell-associated radioactivity of radioiodinated thyroid hormones after 10-min incubation in …