Emerging evidence have posited that dysregulated microglia impair clearance and
containment of amyloid‐β (Aβ) species in the brain, resulting in aberrant buildup of Aβ and …

Microglial dysregulation, pertaining to impairment in phagocytosis, clearance and
containment of amyloid-β (Aβ), and activation of neuroinflammation, has been posited to …

Although many reports have revealed the importance of defective microglia-mediated
amyloid β phagocytosis in Alzheimer's disease (AD), the underlying mechanism remains to …

In Alzheimer's disease (AD), and other conditions affecting integrity of the blood–brain
barrier, microglia can originate in the bone marrow, migrate into the blood and enter the …

Alzheimer's disease is characterized by brain plaques of amyloid beta and by neuronal loss,
but it is unclear how amyloid beta causes neuronal loss and how to prevent this loss. We …

Amyloid-ß (Aß) accumulation in the brain triggers the onset of Alzheimer's disease (AD), and
its prevention and elimination are high priorities for anti-AD therapeutic strategies. Microglia …

Central nervous system microglia promote neuronal regeneration and sequester toxic β-
amyloid (Aβ) deposition during Alzheimer's disease. We show that the cytokine …

Microglial cells consume adenosine triphosphate (ATP) during phagocytosis to clear
neurotoxic β-amyloid in Alzheimer's disease (AD). However, the contribution of energy …

Microglia, the CNS-resident immune cells, play important roles in disease, but the spectrum
of their possible activation states is not well understood. We derived co-regulated gene …

Bruton's tyrosine kinase (BTK), a critical component of B cell receptor signaling, has recently
been implicated in regulation of the peripheral innate immune response. However, the role …