Simple Summary Cancer-associated fibroblasts are important players of the tumour
microenvironment. They influence numerous processes during tumour development and …

Efforts to develop anti-cancer therapies have largely focused on targeting the epithelial
compartment, despite the presence of non-neoplastic stromal components that substantially …

Stroma cells contribute to the microenvironment that is essential for cancer growth, invasion
and metastatic progression. Fibroblasts, often termed myofibroblasts or cancer-associated …

Simple Summary As our knowledge of cancer as a complex organ comprising tumor cells as
well as surrounding cells within the microenvironment continues to grow, it is imperative to …

In malignant tumors, cancer cells adapt to grow within their host tissue. As a cancer
progresses, an accompanying host stromal response evolves within and around the nascent …

The implications of a tumor microenvironment in cancer initiation and progression have
drawn interest in recent years. Within the tumor stroma, fibroblasts represent a predominant …

Simple Summary The tumor microenvironment plays an important role in determining the
biological behavior of several of the more aggressive malignancies. Among the various cell …

Tumours develop within complex tissue environments consisting of aberrant oncogenic
cancer cells, diverse innate and adaptive immune cells, along with structural stromal cells …

Fibroblasts in the tumor stroma are well recognized as having an indispensable role in
carcinogenesis, including in the initiation of epithelial tumor formation. The association …

Simple Summary Cancer-associated fibroblasts (CAFs) play an important contributory role in
the microenvironment of tumors. They originate from different cells, have multiple pro-and …